The Amazing Spider-Man #31: "If This Be My Destiny...!" begins with Spider-Man fighting masked men armed with knock-out gas, working for the anonymous Master Planner as they get away with a stolen nuclear device and escape into the ocean. The next day,
Aunt May falls over and is hospitalized with an unknown illness. Distracted by her condition, Peter Parker is aloof on his first day at
Empire State University and alienates his fellow students, including
Harry Osborn and
Gwen Stacy; not used to being rebuffed, Gwen becomes interested in Peter. At the
Daily Bugle,
Betty Brant struggles to choose between Peter and
Ned Leeds. Reporter
Frederick Foswell learns of the stolen device while undercover and flags Spider-Man down to tell him that the next theft will happen at the pier. Spider-Man thwarts them by wearing a gas mask, and they flee into the water.
The Amazing Spider-Man #32: "Man on a Rampage!" reveals that the Master Planner is
Doctor Octopus. Peter sees Betty at the Daily Bugle and acts dismissively to scare her away, thinking she would not want to date Spider-Man, but she is not fooled by his act. At the hospital, Peter learns Aunt May was poisoned by the radiation in his blood when he had given her a transfusion. He goes to the scientist
Curt Connors, who suggests ordering the ISO-36 serum to treat her. Doctor Octopus also wants the serum and has his men steal the shipment. Spider-Man rampages through criminal hideouts demanding information as Aunt May goes into a coma. Upon finding the Master Planner's underwater headquarters, Spider-Man encounters Doctor Octopus and they fight. Spider-Man fights aggressively and destroys the facility. As it collapses, he is trapped under heavy machinery. Exhausted from the last few days, he watches as water drips in, threatening to wash away the serum.
The Amazing Spider-Man #33: "The Final Chapter!" returns to Spider-Man as he tries to escape from under the machinery. Unwilling to let Aunt May down the way he did his
Uncle Ben, Spider-Man struggles under the weight until he triumphantly lifts it over his head. With an injured leg, he fights through more masked men and stumbles into Conners' lab with the serum. Conners creates the medicine and Spider-Man delivers it to the hospital. To distract himself while waiting for the treatment to take effect, he returns to the crime scene to take photographs that he can sell to the Daily Bugle. Encountering Betty, he successfully scares her away by telling her about the danger of his job as a freelance photojournalist. After selling the pictures, Peter returns to the hospital to see Aunt May as she recovers. == Analysis and themes ==