Evanston to Rock Springs I-80 enters
Uinta County concurrent with US 189 from
Summit County, Utah, west of Evanston, the
county seat of Uinta County. The Interstate parallels the
Union Pacific Railroad's
Evanston Subdivision rail line to Yellow Creek, east of which the railroad parallels the creek northeast, and the highway heads east into the city of Evanston.
I-80 Business (I-80 Bus.) and
US 189 Bus. split northeast onto Harrison Drive. I-80 has an interchange with
WYO 150 (Front Street) just south of downtown Evanston and crosses over the railroad line and the
Bear River shortly before the business routes (which use Bear River Drive) rejoin the Interstate on the eastern edge of the city. I-80 and US 189 continue east through interchanges with Painter Road and Divide Road before the US Highway splits northeast toward
Kemmerer. I-80 parallels
Blacks Fork of the
Green River through interchanges with
WYO 412 and
WYO 414 north of
Mountain View and
WYO 413 north of Lyman before crossing over the river. The Interstate crosses over Smiths Fork, a tributary of Blacks Fork, before I-80 Bus. rejoins the mainline. I-80 has a junction with Church Butte Road before entering
Sweetwater County. The highway meets the western end of
WYO 374 south of
Granger and has a
trumpet interchange with US 30, which joins the Interstate in the first of several concurrencies east to Nebraska. A second segment of WYO 374 begins at the first interchange east of US 30 that serves
Little America. Due to the numerous winter closures along this stretch, the
Wyoming Department of Transportation (WYDOT) has proposed rerouting the highway to the north along US 30.
Laramie to Pine Bluffs East of Laramie, I-80 and US 30 head southeast and cross the
Laramie Mountains. The two highways reach their national high point at
Sherman Summit, where they have an interchange with
WYO 210 (Happy Jack Road). I-80 and US 30 have interchanges with Vedauwoo and Buford roads, the latter at the settlement of
Buford just before the freeway enters
Laramie County. The Interstate and US Highways rejoin the railroad and pass through minor junctions with Remount, Harriman, and Warren roads. I-80 and US 30 meet the western end of
WYO 225 (Otto Road), which they parallel east to Cheyenne. The two highways have an interchange with
WYO 222 (Roundtop Road) just west of a three-ramp
partial cloverleaf interchange with the eastern end of WYO 225 (Otto Road) and the western end of
I-80 Bus. (Lincolnway), onto which US 30 exits. The missing movement from the surface highway to eastbound I-80 is made via the business route's nearby interchange with I-25 and
US 87. I-80 continues east across the Union Pacific Railroad to a full
cloverleaf interchange with I-25 and US 87, where the highway enters the city of Cheyenne, the county seat and state capital. The Interstate crosses over a
BNSF Railway line and has a diamond interchange with
US 85 and the southern end of I-180, a non-freeway spur into downtown Cheyenne. East of I-180, I-80 receives the eastern end of its business route at its junction with
WYO 212 (College Drive). East of its interchange with Campstool Road, the freeway leaves the city of Cheyenne and collects the eastern end of US 30 (Archer Boulevard). I-80 and US 30 have interchanges serving
Hillsdale and
Egbert around a junction with
WYO 213 and
WYO 214, which serve
Burns and
Carpenter, respectively. I-80 and US 30 reapproach the Union Pacific Railroad's
Sidney Subdivision east of Burns and parallel it to Pine Bluffs, the easternmost town in Wyoming. There, US 30 splits north and immediately meets the southern terminus of
WYO 215. At the eastern town limit of Pine Bluffs, I-80 enters
Kimball County, Nebraska. ==History==