Papafis was born to a local Greek family in the city of
Thessaloniki in 1792. Son of Nikolaos Papafis and Tomae Anastassiou, when he turned 16 he moved to
Smyrna to work with his father, a merchant, who died just two years later. His uncle Ioannis Anastasiou (
Giovanni D'Anastasy, 1780/85–1859/60), prosperous merchant-entrepreneur and general consul of
Sweden in
Alexandria, brought him to
Egypt and then sent him to
Malta to open a new branch of the family business. In Malta, a major logistics hub during the
Napoleonic Wars, Papafis managed the
grain trade and learned English and Italian, besides French. He was chaperoned by the British merchant Jameson Hunter and recognised a
denizen of Malta on 13 March 1818, with the right to a British passport. In 1822 Pappafis was appointed a public broker for Malta, work from which he retired 15 years later in 1837 due to health concerns. He continued to deal with financial investments in European stock exchanges, advocating for trade and publishing pamphlets and newspaper articles. In 1858 he was appointed an honorary member of the Stock Exchange by the Chamber of Commerce in Malta. Papafis married Vincenza Rosa Aquilina in 1843, the daughter of
Corsican Catholic merchant Lorenzo Aquilina. They did not have children. In 1843 they moved from
Valletta to
Rabat, Malta. Since then, he mainly dealt with charities, in particular the welfare of orphans and poor young men. In his 1879 and 1883 wills, Papafis provided rich endowments, often anonymously, to charitable institutions in Greece, Salonica, and Malta. He kept an active lifestyle until the age of 90, managing his own investments and correspondence. He died at 94 in Malta. His legacy of philanthropic activities include the founding of orphanages and large donations directed to educational and public services and both in Malta and Greece. He was memorialised with a bust at the
Maglio Gardens in
Floriana, "Erected by the people of Malta to the memory of Giovanni di Nicolò Pappaffy in recognition of his generosity in bequeathing funds to assist emigration". ==
Papafeio Orphanage==