Ethyl butylacetylaminopropionate

IR3535 is effective in repelling several different insects such as mosquitoes species and also midges, ticks and head lice. It is as effective as DEET against Aedes and Culex mosquitoes, but may be less effective than DEET against Anopheles mosquitoes, vectors of malaria. A 2013 review concluded that IR3535 is as effective as 20% DEET against Anopheles, citing that some studies reported possibly shorter protection of just 3.8 hours. IR3535, among other repellents, is included in the World Health Organization (WHO) recommendation for areas with malaria. The WHO also notes that it may be necessary to reapply repellents every 3-4 hours in hot and humid climates. IR3535 also helps prevent bites from ticks that may transmit Lyme disease. == Interactions ==

Few if any studies have evaluated possible interactions when using IR3535 with sunscreens. == Mechanism of action ==

The mechanism of action is still under investigation, but it probably related to the intolerance of mosquitos and other invertebrate animals to its odor. IR3535 is applied topically in human skin and prevent bites from mosquitos and ticks that might cause serious diseases, such as dengue, malaria, zika, West Nile virus, Lyme disease, among others. == Chemistry ==

IR3535 is a derivative of the non-proteinogenic amino acid beta-alanine. == Approval ==

IR3535 is approved by several authorities around the world, including ECHA (Europe) and the EPA (US) where it is considered a biopesticide. == See also ==