It is controlled by
parasympathetic postganglionic fibers releasing acetylcholine acting primarily on the
muscarinic acetylcholine receptor (M3) of iris sphincter muscle. Preganglionic fibers originate from the
Edinger–Westphal nucleus, travel along the
oculomotor nerve (CN III), and make nicotinic cholinergic synapses on neurons in the
ciliary ganglion. Those neurons' postganglionic parasympathetic fibers then enter the eye through the
short ciliary nerves. The short ciliary nerves then run forward and pierce the
sclera at the back of the eye, traveling between the sclera and the
choroid to innervate the iris sphincter muscle. ==See also==