Season 1 (2012) During the first season, Spider-Man is recruited to work for
S.H.I.E.L.D. alongside
Nova,
White Tiger,
Iron Fist, and
Luke Cage, with whom he attends
Midtown High School. Corrupt industrialist
Norman Osborn targets Spider-Man in hopes of collecting his DNA to create a spider-soldier army. To this end, he uses
Doctor Octopus as his pawn, having him send numerous supervillains after Spider-Man and use a sample of Spider-Man's blood to create the
Venom symbiote, which bonds with Norman's son
Harry Osborn. In the two-part season finale, Doctor Octopus takes revenge on Norman for his treatment of him and transforms him into the
Green Goblin. In the ensuing battle, the S.H.I.E.L.D.
Helicarrier is destroyed.
Season 2 (2013) In the second season, the S.H.I.E.L.D. team moves into Peter's house, as they no longer have a home following the Helicarrier's destruction. In the season premiere, after learning that Spider-Man gained his powers from one of Oscorp's genetically altered spiders, Doctor Octopus creates serums with animal DNA in hopes of re-creating the process. S.H.I.E.L.D. scientist Curt Connors, who lost his right arm due to injuries from the Helicarrier's destruction, uses one of the serums to regrow his arm and becomes the
Lizard. Later, Doctor Octopus controls the Lizard so that he can join him,
Electro,
Rhino,
Kraven the Hunter, and
Beetle as a member of the
Sinister Six. While the S.H.I.E.L.D. Team defeat five of the six villains, Connors escapes and Spider-Man swears to find and cure him. Later the Sinister Six reappears with Beetle replaced by
Scorpion. During the season, Spider-Man learns more about his teammates' origins: White Tiger became White Tiger after her father
Hector was killed by Kraven, Nova is an orphan who was raised by the
Guardians of the Galaxy, Danny Rand became Iron Fist after training in
K'un-L'un and left it to further his training, and Luke Cage received his powers from a version of the Super-Soldier Formula developed by his parents. Norman Osborn is cured and becomes
Iron Patriot, but Doctor Octopus later transforms him back into the Green Goblin.
Season 3: Web-Warriors (2014–2015) In the third season, Spider-Man joins the
Avengers, but eventually leaves to rejoin S.H.I.E.L.D. In the aftermath, Venom bonds with
Flash Thompson to become Agent Venom and
Nick Fury tasks Spider-Man to recruit other young heroes to form the
New Warriors, consisting of
Ka-Zar,
Zabu,
Amadeus Cho /
Iron Spider, and
Cloak and Dagger. The New Warriors battle the
Thunderbolts, during which Green Goblin escapes with the
Siege Perilous and travels the
multiverse to collect DNA from Spider-Man's counterparts. Chasing after him, Spider-Man meets up with
Spider-Man 2099,
Spider-Girl,
Spider-Man Noir,
Spider-Ham, Spyder-Knight, and
Miles Morales, and works with them to take down Spider-Goblin and
Electro. After both are defeated and the alternate Spider-Men return to their homes, the Green Goblin reverts into Norman Osborn and sustains amnesia, making him forget his time as the Green Goblin. Afterwards, Spider-Man and his team begin their education at the S.H.I.E.L.D. Academy while dealing with
Arnim Zola. Not long afterwards,
Aunt May, Agent Venom, and Iron Spider learn Spider-Man's identity.
Season 4: vs. the Sinister 6 (2016–2017) In the fourth season, Doctor Octopus allies with Zola and
Hydra and forms a new iteration of the Sinister Six consisting of Kraven the Hunter,
Ultimate Green Goblin, Rhino,
Hydro-Man, and Electro. In response, Spider-Man forms a team consisting of Agent Venom, Iron Spider, Miles Morales, and
Scarlet Spider (
Ben Reilly). It is later revealed that Ben is a clone of Spider-Man created by Doctor Octopus, but Spider-Man convinces him to reform. Later,
Crossbones and
Morbius experiment with Venom, turning New York's citizens into
Carnage-like monsters. Carnage possesses
Mary Jane Watson, but Spider-Man and Harry Osborn free her. Unbeknownst to Spider-Man, a fragment of the Carnage symbiote remains inside Mary Jane's body.
Madame Web learns that the destruction of the Siege Perilous shattered the barrier between universes. Spider-Man and Miles Morales travel to alternate realities to collect the fragments of the Siege Perilous and battle
Wolf Spider, who seeks to reassemble the Siege Perilous to conquer the multiverse. After reassembling the Siege Perilous, Miles moves to the main universe and lets his version of
Gwen Stacy replace him. Spider-Man and Mary Jane later discover a second clone of Spider-Man named
Kaine, who tries to feed off them. During this time, Mary Jane learns to control Carnage and becomes
Spider-Woman. It is discovered that Doctor Octopus and Arnim Zola created Scarlet Spider as part of Weapon S, a project to create synthezoid
Spider-Slayers. Kaine fuses with the synthezoids to become the Ultimate Spider-Slayer, but is defeated by Agent Venom. In the series finale, the Sinister Six capture Spider-Man and use an antidote to remove his powers. After working with Norman Osborn, Peter regains his powers and defeats the Sinister Six. Spider-Man convinces Doctor Octopus to surrender, after which he and the S.H.I.E.L.D. trainees graduate. == Episodes ==