Modeling At the age of 28, her modeling career began, when she was photographed by
Bruce Weber for
British Vogue and by
Bill King for
American Vogue. During her career, she has also worked with many other renowned photographers, including
Richard Avedon,
Steven Meisel,
Helmut Newton,
Peter Lindbergh,
Norman Parkinson,
Eve Arnold,
Francesco Scavullo,
Annie Leibovitz,
Denis Piel, and
Robert Mapplethorpe. Her image has appeared on such magazines as
Marie Claire, ''
Harper's Bazaar, Vanity Fair, and Elle. In March 1988, an exhibition dedicated to photographs of her, called Portrait of a Woman'', was held at the
Musée d'Art Moderne de Paris. Rossellini's modeling career led her into the world of
cosmetics, when she became the exclusive spokesmodel for the French cosmetics brand
Lancôme in 1982, replacing
Nancy Dutiel in the United States and
Carol Alt in Europe. At Lancôme, in 1990, she was involved in product development for the fragrance Trésor. In 1996, when she was 43, she was removed as the face of Lancôme for being "too old". In 2016, at the age of 63, she was rehired by Lancôme's new female CEO, Francoise Lehmann, as a global brand ambassador for the company. In October 1992, Rossellini modelled for
Madonna's controversial book
Sex. Rossellini also appeared in Madonna's music video for her single "
Erotica", released in autumn 1992. Rossellini was the inaugural brand ambassador for the Italian
Silversea Cruises company in 2004, and she appeared in print ads and on their website. Barbara Muckermann, the senior vice-president of worldwide marketing and communications in 2004, said at the time of the announcement, "Isabella is the ideal personification of Silversea's exclusive standard of elegance, glamour and sophistication."
Film and television in Berlin in 1992 to shoot some scenes for the film
The Innocent Rossellini made her film debut with a brief appearance as a nun opposite her mother in the 1976 film
A Matter of Time. Her first role was the 1979 film
The Meadow, and then in 1980 she appeared in
Renzo Arbore's film ''
In the Pope's Eye'' with her then husband
Martin Scorsese. Following her mother's death in 1982, Rossellini was cast in her first American film,
White Nights (1985). This was followed by her notable role as the tortured
nightclub singer Dorothy Vallens in the
David Lynch film
Blue Velvet, in which she also contributed her own singing, most notably covering "
Blue Velvet" (1951). Other significant film roles during this period include her work in
Cousins (1989),
Death Becomes Her (1992),
Fearless (1993), and
Immortal Beloved (1994). In 1996, she appeared as herself in an episode of the TV series
Friends called "
The One with Frank Jr." In 2003, Rossellini was a recurring character on the television series
Alias. In that same year, she also appeared in the Canadian film
The Saddest Music in the World, directed by
Guy Maddin. In 2004, she played the High Priestess Thar in the
Sci-Fi Channel miniseries
Legend of Earthsea, and the director
Robert Lieberman stated that Rossellini "brings a very big persona to the screen. She carries a great deal of beauty. We needed someone who had a feeling of authority to be this kind of mother superior type and at the same time not be totally dour and unattractive." In 2006, Rossellini appeared in several television documentaries. First, she narrated a two-hour television special on Italy for the
Discovery Channel's
Discovery Atlas series. Then, alongside
Segway PT inventor
Dean Kamen, she spoke about her past and current activities on an episode of
Iconoclasts, a series that featured on the
Sundance Channel (known as SundanceTV from 2014 onwards), an independent film network founded by film industry veteran
Robert Redford. The Sundance Channel then purchased the 2006 Guy Maddin-directed short film
My Dad Is 100 Years Old, a tribute that Rossellini created for her father. In the film, she played almost every role, including
Federico Fellini,
Alfred Hitchcock and her mother, Ingrid Bergman. Rossellini's twin sister, Isotta Ingrid, criticized the short film, calling it an "inappropriate" tribute. In 2007, Rossellini guest starred on two episodes of the television show
30 Rock, playing
Alec Baldwin's character
Jack Donaghy's ex-wife. Around the same time, Rossellini enrolled at
New York University where she undertook an undergraduate degree in Art and Environmental Studies, and then pursued with a master's degree at
Hunter College in New York to study animal behavior. Then the Sundance Channel commissioned her to contribute a short-film project to the environmental program
The Green.
Green Porno was followed by two other animal-themed television productions:
Seduce Me: The Spawn of Green Porno and
Mammas.
Seduce Me: The Spawn of Green Porno is a five-episode online series that was premiered in mid-2010 and explores the topic of animal courtship. As with
Green Porno, Rossellini wrote, directed and acted in the series; she is also a producer of the series. Rossellini explained in 2010, "I always wanted to make films about animals – there's not an enormous audience, but there's an enormous audience for sex."
Mammas debuted in the United States on 12 May 2013, Mother's Day weekend there, and is a celebration of the maternal aspects of the animal world. Rossellini is again the primary actor and plays the maternal versions of animals such as spiders and hamsters. Rossellini explained in a 2013 interview part of the research process for
Mammas: "First of all it's about diversity. When talking about motherhood, I would find examples of ten different species that either don't get pregnant in the belly but in the mouth or back. Or species that abandon their children all-together so that I don't tell ten stories that are too similar." in Vladislav Alex Kozlov's
Silent Life: The Story of the Lady in Black, a feature-length version of the director's silent, black-and-white short film
Daydreams of Rudolph Valentino. Kozlov's film was due for release in 2012, but, as of February 2014, the film has not been officially released. Rossellini was the president of the jury for the
61st Berlin International Film Festival in 2011. In April 2015, she was announced as the president of the jury for the section of the
2015 Cannes Film Festival. In 2016, Rossellini was cast as Rita Marks, the matriarch of the Marks crime family in the
Hulu original series,
Shut Eye. In 2023, Rossellini was honoured with Lifetime Achievement Award at the
18th Rome Film Festival. In 2024, Rossellini received acclaim for her portrayal of Sister Agnes in the political drama,
Conclave, opposite
Ralph Fiennes,
Stanley Tucci and
John Lithgow, for which she received a
Best Supporting Actress nomination at the
97th Academy Awards. On February 15, 2025, it was announced that Rossellini would be joining the cast of
Ryan Murphy's upcoming television series,
The Beauty. On February 26, 2025, it was announced that she had been cast in
Mike Newell's
Wallis Simpson biopic,
The Bitter End, playing opposite
Joan Collins. Rossellini is also set to star in
Jeremiah Zagar's upcoming film
The Painted Bride, alongside actors
Jeremy Allen White and
Mandy Patinkin. The distribution rights to a documentary starring Rossellini,
A Season with Isabella Rossellini, were secured by Escapade Media in September 2025. The documentary, directed by Marian Lacombe, sees Rossellini reflecting on her life as a celebrated model as well as her colorful life. Rossellini was cast in Marco Perego's film
Petrichor shot in Italy over the summer of 2025. In May 2026, it was announced that Rossellini had been cast and was currently filming
Alice Rohrwacher's
Three Incestuous Sisters. ==Stage and live performance==