Lopresti unsuccessfully stood as the Conservative candidate in the Bedminster ward of
Bristol City Council in 1995. He was again unsuccessful when he stood in Hartcliffe ward in 1997 and Redland ward in 1998, but was subsequently elected in the
Stockwood Ward in 1999. He worked as councillor in that ward until May 2007, when he stood down and a new Conservative candidate won the seat. He stood unsuccessfully as the Conservative Party candidate for the
Bristol East constituency in
2001, and for the
South West at the European Parliament elections in 2004. Although the Conservative Party did win three seats in the region, Lopresti was the sixth candidate for the seven seats that were available. Lopresti was a member of the Conservative Party's
A-List in 2006. At the
2010 general election, he was first elected as
Member of Parliament (MP) for
Filton and Bradley Stoke, a constituency newly created after
boundary changes. In 2011, he was a member of the special
Select Committee set up to scrutinise the Bill that became the
Armed Forces Act 2011. and attended delegations of that group including during the
Operation Defensive Shield conflict when he visited in 2014 for an Israeli military briefing on the
Iron Dome air defence system. At the
2015 general election, he retained his seat with an increased majority of almost 10,000 votes. Lopresti supported
Brexit in the
2016 EU referendum. Lopresti was subject to a failed attempt before the
2017 general election by some members of his local party to deselect him as the Conservative Candidate for Filton and Bradley Stoke. This followed reports in the press that he had been having an
extramarital affair with a fellow MP. There was, he said, a "vicious smear campaign" in the constituency and an "attempt to destroy my character and reputation" after revelations about his private life. Lopresti said he had made a complaint to the police over a letter urging Lopresti's deselection, which had been circulated by a "former very bitter party member and possibly a disgruntled employee", and appeared to have broken data protection laws. He was re-selected. At the
2017 UK general election, he retained his seat, but with a decreased majority. In Parliament, Lopresti served on the Northern Ireland Affairs Committee, Armed Forces Bill Committee and Defence Committee. In December 2017,
BBC News Online reported that Lopresti was facing an investigation after his ex-office manager made a formal complaint about his behaviour, following her resignation. A senior Conservative councillor in Bristol subsequently claimed there were "ample grounds" to believe the bullying allegations surrounding the MP due to his "character flaws" and past behaviour. However, two former staff members said they had had a good relationship with Lopresti, and that he was a good employer. Subsequent to this, the BBC reported on 11 July 2019 that the ex-office manager, Jo Kinsey, felt she had been 'vindicated' following her complaint, having received a letter of apology from Lopresti following an internal Conservative party investigation. Lopresti said he categorically rejected the allegations, and had concerns about the inquiry process. In the
December 2019 general election, Lopresti retained his seat once again, with a slightly greater majority than in 2017. On 8 April 2020 during the
coronavirus pandemic, Lopresti sent a letter to cabinet minister
Robert Jenrick asking him to reopen churches for
Easter. Lopresti was appointed Deputy Chairman of the Conservative Party, serving alongside Nickie Aiken, Lee Anderson, Luke Hall and Matthew Vickers from 2023. Lopresti lost his seat in parliament in the general election of 4 July 2024, gaining 12,905 votes compared to Labour's
Claire Hazelgrove with 22,905. ==Post-parliamentary career==