Meir was born in
Jerusalem in 1856, the son of successful merchant Calev Mercado. He studied the
Talmud under Rabbi Menachem Bechor Yitzhak, and at age 15 began to study
Kabbalah under Rabbi
Aharon Azriel, an elder of the
Beit El Synagogue. He married his wife Rachel at age 17, and continued to study Torah in the years after his marriage. He was among the founders of a
Bikur cholim society in 1879 which established the
Misgav Ladach Hospital in Jerusalem. In 1882, he was sent to
Bukhara as the first
emissary to visit there. He was received with great respect by the
Jews of Bukhara, and children were named for him during his stay. He was instrumental in encouraging the
immigration of Bukhara Jews to the Land of Israel. and together with
Eliezer Ben-Yehuda,
Chaim Hirschensohn, and Chaim Kalmi, he co-founded the Safa Brura ("clear language") association, which was created in 1889 to teach and encourage the use of Hebrew. He was a founding member of the Hebrew Language Committee, which was established by Ben-Yehuda in 1890 and was later succeeded by the
Academy of the Hebrew Language. In 1899, Meir was appointed deputy head of the Beth Din of Rabbi Raphael Yitzhak Yisrael. Following Elyashar's death in 1906, he was picked to succeed him as the chief rabbi of Jerusalem, but his appointment was vetoed by his opponents, supported by the
Hakham Bashi in Constantinople, because of his Zionist affiliations. He was subsequently inducted as Hakham Bashi of Palestine but six months later, he was deposed by the Sultan of Turkey, and
Eliyahu Moshe Panigel took charge of overseeing the Orthodox community. ==Salonica==