In 1962, the State Department sponsored a cultural exchange tour and engaged DePreist as an American specialist in music. The tour was to cover the Near and the Far East with DePreist lecturing and performing jazz. While on tour in Thailand and attending a Bangkok orchestra rehearsal, he was asked if he wanted to conduct. This experience caused DePreist to realize he wanted to be a conductor. During the tour DePreist contracted
poliomyelitis. However he recovered sufficiently, allowing him to enter and to ultimately claim first prize in the Dimitri Mitropoulos International Conducting Competition. During his 23-year tenure, he led the transformation of the Oregon Symphony from a small, part-time orchestra to a nationally recognized group with a number of recordings. Peter Frajola, a principal violinist who joined the orchestra in the 1980s recalled "phenomenal musical journeys" with DePreist whose influence reached far beyond the music hall into the community. He was the symphony's ninth music director His other leadership roles with orchestras include tenures with the Orchestre Symphonique de Québec, the
Malmö Symphony Orchestra in Sweden, and the
Monte-Carlo Philharmonic Orchestra. He also served as artistic advisor to the
Pasadena Symphony. As guest conductor, DePreist appeared with every major North American orchestra, including the
Boston Symphony Orchestra, the
Philadelphia Orchestra, the
Symphony of the New World, and
Juilliard Orchestra. He also led orchestras in Helsinki, Rome, Sydney, Tokyo, London, and many other cities. ==Awards==