In 1746, Isham returned to the Bay and once again became chief factor at
York Factory. For the second time in his career, two ships spent the winter in the vicinity of the fort. The crews of the Dobbs Galley and the California were looking for the
Northwest Passage and, just as with the earlier voyage by Middleton, they were unsuccessful. Isham was pulled into the conflict between the two captains, William Moor and Frances Smith, during their time at York Factory. When they returned to England one of the crew published an article critical of Isham's support. In 1748, Isham was recalled to England again. While there, he published a rebuttal to ‘A Voyage to Hudson’s Bay in the Dobbs Galley’ written by
Henry Ellis. Isham was also one of the witnesses who testified before the
British Parliament in 1749 when the HBC Charter was challenged. Eventually, the Charter was confirmed. In the last decade of his career, Isham turned his attention to the French competition trading out of
Montreal. The
voyageurs made annual trips in large canoes, meeting the indigenous people in their own territories and returning in the fall to Montreal with a load of furs. Gradually, they built a series of forts along the HBC river routes so they could intercept the
Cree and
Assiniboine traders before they reached
York Factory and other forts on the Bay. In 1754, Isham sent the first of nine groups of men inland to encourage distant tribes to come to York Factory to trade. Anthony Henday led the first group and became known as the first European to see the eastern edge of the
Rocky Mountains. Subsequent trips organized by Isham had some success in bringing clients to the Bay and they also increased the HBC's knowledge of inland routes, which would be essential in the following years when the company began to build forts inland to compete with the Montreal traders. Isham died on April 13, 1761, of kidney failure, following twenty years of gout and kidney stones. He was buried at
York Factory (the second site, which was abandoned a few years later). == Descendants ==