Upon returning to Amelia County in November 1796, Dr. Jones practiced medicine and also helped his father operate plantations using enslaved labor, as had his grandfather and great-grandfather. He built a plantation house in the Georgian style which is now a National Historic Landmark. In 1820, the first census after his father's death, Jones owned 30 enslaved people in Nottoway County. In the last federal census of his life, Jones owned 56 enslaved people in Nottoway County. He supported education (serving on the Hampden-Sydney Board of Trustees for decades), opposed high tariffs and in 1822 was president of Nottoway's agricultural society when he wrote a paper published in the
American Farmer. In his will, he manumitted all his slaves and advised them to move to Liberia. Meanwhile, Nottoway County voters elected Jones as one of their representatives (part-time) in the
Virginia House of Delegates in 1804, and re-elected him annually until 1809. Thus he served first alongside veteran Tyree G. Bacon, then twice alongside Griffin Lamkin, and twice alongside John Fitzgerald. Then from 1809 until he resigned in 1811, Jones served on the Virginia Governor's Council. During the
War of 1812, Jones initially served as surgeon of the local militia led by his brother Capt. Richard Jones, but was promoted to become director general of hospital and medical stores. Jones failed to win election to the
Fifteenth Congress to fill the vacancy caused by the death of
Peterson Goodwyn, but two years later was elected as a
Democratic-Republican to the
Sixteenth and re-elected to the
Seventeenth Congresses (March 4, 1819 – March 3, 1823). He announced his retirement following the redistricting caused by the 1820 census, and was succeeded by Congressman William McCoy of Pendleton County far to the west. Upon leaving Congress, Jones resumed farming and his educational advocacy. Nottoway County voters again elected Jones to the Virginia House of Delegates in 1827 and re-elected him once, before replacing both him and veteran legislator Hezekiah Anderson in late 1829. Anderson owned and adjacent plantation, as well as worked with Capt. Richard Jones, as president of the Bellefonte Jockey Club. In 1825, Virginia's legislature had allowed incorporation of a company to create a canal to make Deep Creek navigable from Nottoway County until its drainage into the Appomattox River, allowing stock valued at $8300. Jones and his probable relative Robert Jones were among the 14 landowners who signed a right-of-way and release of damage claims to the Deep Creek Company. ==Personal life==