Clausen was born in Nr.
Eskilstrup, Soderup parish on the island of
Zealand, Denmark. He was the son of Christen Augustinus Clausen (1858-1938) and Christine (Christensen) Clausen (1856-1933). His parents were farmers and at age 14 he took responsibility for the family farm and was largely educated at home with the assistance of a local school teacher. He studied
Mendel's genetics and
Darwinian evolutionary theory. In 1913 he entered the
University of Copenhagen, where he studied
botany,
genetics and
ecology.
Christen Raunkiær suggested he undertake graduate studies and Clausen chose to study the genetics and ecology of the plant family
Violaceae. He studied hybridization patterns across a range of environments and described
introgression of genes between species. He completed his master's degree in 1920 and was appointed assistant professor to geneticist
Øjvind Winge at the
Royal Veterinary and Agricultural University in Copenhagen. {{cite web In 1926, Clausen was awarded his
Ph.D. for his work on Violaceae; his monograph was one of the first publications that combined systematics, ecology and genetics for any plant group. During 1927-1928, Clausen received a Rockefeller scholarship to study at the
University of California, Berkeley where he worked on the genetics of the genus
Crepis with
E. B. Babcock. During this time he met Californian botanist
Harvey Monroe Hall, who invited Clausen to return to the United States to work on the
ecological genetics of
Californian
native species. Clausen returned to the
California in 1931 as a staff member at the
Carnegie Institution of Washington Department of Plant Biology at
Stanford, California. He would become a naturalized citizen of the United States during 1943. With
taxonomist David D. Keck and physiologist
William Hiesey, he formed the first interdisciplinary effort to combine
genetics,
ecology and
systematics in order to understand the
ecological genetics of the
evolutionary process in
California plants. The project lasted 20 years during which they performed some of the classic experiments in
plant ecology in which they looked at species formation across
Altitudinal zonation using experimental plots at Stanford (near sea level), at Mather near
Yosemite National Park (at about 4,600 feet), and at Timberline in the
Sierra Nevada (at about 10,000 feet).{{cite web ==Works==