After college, Ryan pursued acting full-time in Los Angeles. She made her acting debut in ''
Who's the Boss?, and followed that with guest-starring roles in television series such as Melrose Place, Matlock, and The Sentinel'', as well as TV movies. She had a regular role as extraterrestrial investigator Juliet Stuart on the television series
Dark Skies, which was cancelled after one season. In 1997, Ryan was chosen for a role on the science-fiction series
Star Trek: Voyager as
Seven of Nine, a
Borg drone who was freed from the Borg's collective consciousness. When she joined the cast in season four, ratings increased 60%. After
Voyager ended in 2001, Ryan joined the cast of
Boston Public as Veronica "Ronnie" Cooke, a frustrated lawyer who becomes a high-school teacher.
David E. Kelley, the series' producer, wrote the role specifically for her. The series ended in 2004. Ryan appeared in the romantic-comedy film
Down with Love and as Lydia in the independent film
Men Cry Bullets. Her first film lead was in
The Last Man as the last woman left on Earth. In 2005, she had a role in a TV pilot titled
Commuters, a suburban version of
Desperate Housewives. She had a recurring role as
Charlotte Morgan on
The O.C. in 2005, and she guest-starred as Courtney Reece on David E. Kelley's
Boston Legal in 2006. Ryan then co-starred in the legal drama
Shark as Los Angeles County District Attorney Jessica Devlin alongside series lead
James Woods, but she did not return for episodes aired after the
2007–2008 Writers Guild of America strike; she was credited in all four episodes. CBS cancelled the broadcast of the series after its
season-two finale. She guest-starred as defense attorney Patrice La Rue on the April 7, 2009, episode of
Law & Order: Special Victims Unit, her first role since giving birth to her daughter Gisele. Ryan next had a seven-episode role on the drama
Leverage in season two as a
grifter named Tara Cole, filling in while series regular
Gina Bellman was on maternity leave. She was in
Kevin Tancharoen's short film "
Mortal Kombat: Rebirth" as
Sonya Blade. Although originally a film, it was marketed as a web series, with previews scheduled to appear online in June 2010. The web series
Mortal Kombat: Legacy officially launched in March 2011. Ryan was a regular in the series
Body of Proof, which premiered on March 29, 2011. Ryan continued to appear in guest roles on genre television series, including the science-fiction series
Warehouse 13 as Marine Major Amanda Lattimer, ex-wife of the series' male lead character
Pete Lattimer, in the episode "Queen for a Day". She made a return guest appearance on the drama
Leverage in season four, episode 13 as grifter Tara Cole, in the episode "The Girls' Night Out Job". She also appeared for a multiepisode arc in season one of the science-fiction series
Helix. She was next seen in the series
Star Trek: Picard, reprising her role as Seven of Nine. ==Personal life==