UANL Jesús Molina debuted with
Tigres UANL on 24 August 2007 in a 1–2 defeat against
Veracruz. During the Apertura 2007 tournament he made eight appearances under then-manager
Américo Gallego. The following Clausura 2008 tournament, Molina only made one appearance against
Pachuca in a 1–6 defeat on 14 February. Molina scored his first goal for UANL on 10 May 2009 in a 1–1 draw against
Monarcas Morelia. During the Clausura 2010 tournament, Molina scored six goals in thirteen appearances. For the Clausura 2011, his final tournament with UANL, Molina made sixteen appearances and scored one goal.
América On 8 June 2011 Molina was officially transferred to
Club América for the Apertura 2011 tournament. He made his official debut on 24 July 2011 in a 2–1 victory against
Querétaro. He then went on to become a champion with América in the Clausura 2013 tournament and in the Apertura 2014 tournament. Molina scored his first goal for América on 25 February 2012 in a 4–0 victory against
Atlante.
Santos Laguna On 1 January 2015 Molina was officially transferred to
Santos Laguna for the Clausura 2015 tournament. He made his official debut on 18 January 2015 in a 0–1 loss against
Cruz Azul. He then went to become a champion with
Santos Laguna in the Clausura 2015 tournament. Molina scored his first goal for Santos Laguna on 24 January 2015 in a 4–1 victory against
Monterrey.
Monterrey In December 2016, Molina joined
C.F. Monterrey.
Guadalajara In December 2018, Molina joined
C.D. Guadalajara. On 6 January 2019, he made his debut with Guadalajara, as a starter, in a 2–0 victory over
Club Tijuana. On 27 October, he scored his first goal with Guadalajara in a 2–1 victory over
Juárez. Shortly after the arrival of
Tomás Boy as new manager of the club, in June 2019, Molina was named
captain of the team for the
upcoming season. ==International career==