Medvedow was appointed Director of the ICA in 1998. Her time as Director is most notable for the construction of a new ICA building on the Boston waterfront, which has established the ICA as a major cultural institution in Boston and facilitated an enormous growth in museum membership and attendance. Under Medvedow, the ICA took a chance on hiring architecture firm
Diller Scofidio + Renfro to design the new museum, offering the now-prominent team their first commission for a building in the United States. The new ICA was the first museum built in Boston in a century and a catalyst for the development of Boston's waterfront. In Medvedow's time as ICA Director, annual attendance at the museum has increased from 25,000 to 280,000. Membership has increased sevenfold. Under Medvedow, the ICA has also acquired a permanent collection for the first time. The ICA's teen programs, a focus of Medvedow's tenure, have been recognized by the White House as national models. During this period, the ICA has also continued to organize landmark contemporary art exhibitions. Medvedow has also led two major capital campaigns, raising funds to build the new ICA building and to create a meaningful endowment for the museum. In 2018, under Medvedow’s leadership, the ICA opened the Watershed, transforming a 15,000-square-foot, former copper pipe and sheet metal factory in East Boston into a vast space for experiencing large-scale art, free of charge to all. The Watershed was closed to the public in 2020 due to the Covid-19 pandemic and the site was used to distribute boxes of food and art kits to the East Boston community from April 2020 through December 2021, serving approximately 50,000 people. Medvedow served as co-commissioner of the Venice Biennale in 2022 with the historic selection of
Simone Leigh, the first Black American woman to represent the U.S. at the Biennale, the world’s most prestigious contemporary art exhibition. == Awards, honors, and civic service ==