• Jin Minakata:
Brain surgeon in the present day. Portrayed by
Takao Osawa. • Saki Tachibana: Daughter of
samurai family, a crew of ''Jin'yudo'' clinic. Portrayed by
Haruka Ayase. • Miki Tomonaga: Pediatrician, Jin's fiancée. Portrayed by
Miki Nakatani. Appeared in the TV drama only. • Nokaze:
Oiran who bears an uncanny resemblance to Jin's fiancée. Portrayed by
Miki Nakatani. • Kyotaro Tachibana:
Hatamoto, Saki's elder brother. Portrayed by
Keisuke Koide. • Yusuke Saburi: Western doctor, a crew of ''Jin'yudo'' clinic. Portrayed by
Kenta Kiritani • Jun'an Yamada: Western doctor, a crew of ''Jin'yudo'' clinic. Portrayed by
Hiromasa Taguchi. •
Kōan Ogata: President of Western Medical School. Portrayed by
Tetsuya Takeda. • Tatsugorō Shinmon: President of the fireservice. Portrayed by
Atsuo Nakamura. • Ei Tachibana: Widow of samurai family, Kyotaro and Saki's mother. Portrayed by
Yumi Asō. •
Rintaro Katsu: Vassal of the
Tokugawa shogunate, Kyotaro and Ryoma's boss. Portrayed by
Fumiyo Kohinata. •
Sakamoto Ryōma: Loyalist in
Tosa Province. Portrayed by
Masaaki Uchino. •
Kichinosuke Saigō: Samurai in
Satsuma Province. Portrayed by
Takahiro Fujimoto. • Shusuke Higashi: Samurai in
Chōshū Province. Portrayed by
Ryuta Sato. •
Shintaro Nakaoka: Loyalist in Tosa Province. Portrayed by
Kamejiro Ichikawa II. •
Isami Kondo: President of
Shinsengumi. Portrayed by
Kazufumi Miyazawa. •
Princess Kazu: Wife of 14th
shōgun Iemochi. Portrayed by
Tomoka Kurokawa. •
Shozan Sakuma:
Politician in
Matsushiro Domain, professor of Rintaro and Ryoma. Portrayed by
Masachika Ichimura. ==Live-action adaptations==