Pre-draft Coming out of college, some analysts and scouts graded Mixon as a first-round talent but projected him to be selected in the third or fourth round due to his prior history. He was ranked the fifth-best running back by NFLDraftScout.com, the fourth-best by
Sports Illustrated, and the third-best back by
Pro Football Focus. Although he was a talented prospect, the NFL declined to invite him to the
NFL Scouting Combine. ESPN reported that on the weekend of the combine the
Cincinnati Bengals met with Mixon in order for them to get a chance to talk with him extensively about his character. On March 8, 2017, Mixon performed all of the combine tests and completed the positional workouts at Oklahoma's
Pro Day.
Cincinnati Bengals 2017 Mixon was selected by the Bengals in the second round (48th overall) of the 2017 NFL Draft. He was the fourth running back to be selected in that year's draft. He was viewed as a first-round talent by some scouts, but several teams removed him from their draft board entirely due to character concerns after a prior assault on Amelia Molitor, a female student at Oklahoma.
New England Patriots owner
Robert Kraft said, "While I believe in second chances and giving players an opportunity for redemption, I also believe that playing in the NFL is a privilege, not a right. For me, personally, I believe that privilege is lost for men who have a history of abusing women." After Mixon was drafted,
ESPN writer Dan Graziano wrote that, "No 2017 draft pick enters the league under more intense scrutiny or controversy." The editorial board of Cincinnati TV station
WCPO criticized the draft pick and called for a boycott of the Bengals, writing, "Instead of buying a Bengals ticket this year, take the $50 or more you would have spent on that ticket and donate the money to a nonprofit that works to prevent violence against women." On June 2, 2017, the Bengals signed Mixon to a four-year, $5.45 million contract with $2.81 million guaranteed and a signing bonus of $2.10 million. On September 10, 2017, Mixon made his NFL debut in a 20–0 loss to the
Baltimore Ravens. He had eight rushes for nine yards and three receptions for 15 yards. In Week 3, against the
Green Bay Packers, his role in the offense expanded with 18 carries for 62 yards. In Week 5, against the
Buffalo Bills, he recorded his first career rushing touchdown, a five-yard rush in the fourth quarter. In Week 8, against the
Indianapolis Colts, he recorded over 100 scrimmage yards (18 rushing and 91 receiving) for the first time in his career, 67 of them coming on a long run-after-catch play in the second quarter. After three disappointing weeks of 31 rushing yards against the
Jacksonville Jaguars, 37 rushing yards against the
Tennessee Titans, and 49 rushing yards against the
Denver Broncos, averaging just 2.79 yards per carry over the time span but recording two touchdowns, Mixon led the NFL in Week 12 with a career-best 114 rushing yards against the
Cleveland Browns, along with a touchdown and 51 yards receiving. Mixon closed out his rookie season with 96 rushing yards against the Ravens in the 31–27 victory. Overall, in his rookie season, Mixon finished with 626 rushing yards, 4 rushing touchdowns, 30 receptions, and 287 receiving yards.
2018 In the 2018 season opener against the Colts, Mixon started the season off with 95 rushing yards, a rushing touchdown, and five receptions for 54 yards in the 34–23 victory. In the next game against the Ravens, Mixon had to leave the game multiple times due to a knee injury. He returned to action in Week 5 against the
Miami Dolphins with 93 rushing yards, 22 receiving yards, and a receiving touchdown in the 27–17 victory. In Week 8, against the
Tampa Bay Buccaneers, he had 123 rushing yards and two rushing touchdowns in the 37–34 victory for his second-career multi-touchdown game. On December 9, Mixon racked up 111 yards and a score on the ground against the
Los Angeles Chargers. In Week 15 against the
Oakland Raiders, Mixon rushed for 129 yards and two touchdowns in a 30–16 win. This was the third multi-touchdown game of Mixon's career. He finished the season leading the
AFC in rushing yards with 1,168. In addition, he had eight rushing touchdowns and one receiving touchdown.
2019 in 2019 In Week 3 against the Bills, Mixon rushed 15 times for 61 yards and caught two passes for 34 yards and a touchdown as the Bengals lost 21–17. In Week 10 against the Ravens, Mixon rushed a season high 30 times for 114 yards in the 49–13 loss. In Week 11 against the Raiders, Mixon rushed 15 times for 86 yards and his first rushing touchdown of the season in the 17–10 loss. In Week 14 against the Browns, Mixon finished the game with 23 rushes for 146 yards and a touchdown and three catches for 40 yards as the Bengals lost 27–19. During Week 15 against the Patriots, Mixon finished with 25 rush attempts for 136 rushing yards as the Bengals lost 34–13. In Week 17 against the Browns, Mixon rushed 26 times for 162 yards and two touchdowns during the 33–23 win. In the 2019 season, Mixon finished with 1,137 rushing yards and five rushing touchdowns to go along with 35 receptions for 287 receiving yards and three receiving touchdowns.
2020 On September 1, 2020, Mixon signed a four-year, $48 million contract extension with the Bengals through the 2024 season. In Week 4, against the Jaguars, Mixon had 25 carries for 151 rushing yards and two rushing touchdowns to go along with six receptions for 30 receiving yards and one receiving touchdown during the 33–25 win. Mixon was named the AFC Offensive Player of the Week for his performance in Week 4. In Week 6, he suffered a foot injury and missed the next three games before being placed on injured reserve on November 21, 2020. In the 2020 season, Mixon finished with 428 rushing yards and three rushing touchdowns to go along with 21 receptions for 138 receiving yards and a receiving touchdown in six games.
2021 During Week 1 against the
Minnesota Vikings, Mixon finished with 127 rushing yards and a touchdown as the Bengals won 27–24 in overtime. In Week 11, against the
Las Vegas Raiders, he had 121 rushing yards and two touchdowns. In Week 12, Mixon had 165 rushing yards and two touchdowns in a 41–10 win over the
Pittsburgh Steelers, earning AFC Offensive Player of the Week. In December, Mixon was selected to his first
Pro Bowl, making him the first Bengals running back to make the Pro Bowl since
Rudi Johnson in 2004. On January 5, 2022, Mixon was revealed to have tested positive for
COVID-19, and thus could not play in the season finale. Overall, Mixon finished the 2021 season with a career high 1,205 rushing yards and 13 rushing touchdowns to go along with 42 receptions for 314 receiving yards and 3 receiving touchdowns. Mixon's 13 rushing touchdowns were the most by a Bengals player since
Ickey Woods had 15 in the 1988 season. In
Super Bowl LVI, Mixon rushed for 72 yards, and threw his first career pass attempt, a 6-yard passing touchdown to
Tee Higgins in the 23–20 loss to the
Los Angeles Rams. He was the third running back in NFL history to throw a touchdown in the Super Bowl. He was ranked 38th by his fellow players on the
NFL Top 100 Players of 2022.
2022 In the Bengals' season-opener, Mixon had 145 scrimmage yards in the 23–20 overtime loss to the Steelers. In Week 9 against the
Carolina Panthers, Mixon rushed for 153 yards, had 58 receiving yards, and a career-high, franchise record, five touchdowns in the 42–21 win. He was named AFC Offensive Player of the Week for his game against the Panthers. In the 2022 season, Mixon finished with 210 carries for 814 rushing yards and seven rushing touchdowns to go along with 60 receptions for 441 receiving yards and two receiving touchdowns in 14 games and starts. In the
Divisional Round against the Bills, he had 20 carries for 105 yards and a touchdown in the 27–10 victory.
2023 Mixon began the season by restructuring his contract to a more team-friendly, incentive based deal. He scored his first touchdown of the season in Week 3 against the
Los Angeles Rams, and had his first combined 100-yard game in Week 8 against the
San Francisco 49ers. He would have a two-touchdown game against the Jacksonville Jaguars in Week 13, and had his first and only 100-yard rushing game of the season against the
Cleveland Browns in Week 18. Mixon finished the 2023 season with 1,034 rushing yards and 12 combined touchdowns. He moved into third place for the Bengals' franchise rushing leader, behind James Brooks and
Corey Dillon. He was selected as a first alternate to the
Pro Bowl.
Houston Texans Mixon was traded to the
Houston Texans on March 13, 2024, in exchange for a 2024 seventh round selection previously obtained from the
Arizona Cardinals, which the Bengals used to select
safety Daijahn Anthony. The next day, he signed a three-year, $27 million contract extension through the 2026 season. In his Texans debut against the Colts on September 8, Mixon recorded his third-highest career rushing output in a single game as he finished with 159 yards with a touchdown in a 29–27 win, earning AFC Offensive Player of the Week. He missed three games from Week 3 to Week 5 with an ankle injury. In his return in Week 6, he had 132 scrimmage yards, a rushing touchdown, and a receiving touchdown in the 41–21 win over the Patriots. In the following game against the Packers, he had 25 carries for 115 yards and two touchdowns in the 24–22 loss. In the following three games, he scored a touchdown in each game and went over 100 rushing yards in two of them. In Week 11 against the Cowboys, he had 20 carries for 109 yards and three touchdowns in the 34–10 win. In Week 13 against the Jaguars, he became the only player in NFL history to have at least 100 rushing yards and a rushing touchdown in six consecutive road games. He finished the 2024 season with 245 carries for 1,016 rushing yards and 11 rushing touchdowns to go with 36 receptions for 309 receiving yards and one receiving touchdown. In the Wild Card Round of the playoffs, he had 25 carries for 106 rushing yards and one rushing touchdown in the 32–12 win over the Chargers. He had 100 scrimmage yards and a rushing touchdown in the 23–14 loss to the Chiefs in the Divisional Round. Mixon missed the entirety of the 2025 season with a leg injury. On March 6, 2026, Mixon was released by the Texans. ==Career statistics==