•
Sir John Henderson, 5th Baronet (1752–1817), British Member of Parliament (MP) for Seaford, 1785–86 •
John Henderson (Maryland politician), American politician from Maryland •
John Henderson (Mississippi politician) (1797–1857), United States Senator •
John Henderson (Durham MP) (1811–1884), British Liberal MP for Durham 1864–74 •
John D. Henderson, American editor and pro-slavery politician •
John B. Henderson (1826–1913), U.S. Senator and author of 13th Amendment to U.S. Constitution •
John A. Henderson (1841–1904), corporate lawyer and politician in Florida •
John S. Henderson (1846–1916), Representative from North Carolina's 7th district •
John Henderson (West Aberdeenshire MP) (1846–1922), Scottish chartered accountant, barrister and Liberal Member of Parliament •
John M. Henderson (1868–1947), American politician (Texas House, 1907–09; Texas Senate, 1915–19) •
John Henderson (Conservative politician) (1888–1975), Conservative MP for Glasgow Cathcart, 1946–1964 •
John Craik-Henderson (1890–1971), British Conservative Party politician •
John E. Henderson (1917–1994), American politician (R–OH) •
John Ward Henderson (1874–1925), American politician in Florida ==Sport==