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John Hughes (Middlesex MP) (fl. 1542–1552), English Member of Parliament for Middlesex •
John Hughes (Pennsylvania politician) (1711–1772), colonial Pennsylvania politician •
John Bristow Hughes (1817–1881), grazier, developer and politician in the early days of the Colony of South Australia •
John Hughes (New South Wales politician) (1857–1912), Australian politician •
John T. Hughes (politician) (1873–1921), American politician from Arizona, member of the 1st Arizona state legislature •
John Chambers Hughes (1891–1971), United States diplomat; ambassador to NATO •
John H. Hughes (politician) (1904–1972), New York state senator •
John Hughes (Coventry North East MP) (1925–2009), MP for Coventry North East •
John T. Hughes (intelligence officer) (1928–1992), U.S. Defense Intelligence Agency officer •
John Owen Hughes (1881–1945), British businessman and politician in Hong Kong •
John Hughes (British diplomat) (born 1947), British diplomat and Ambassador to Argentina •
John Hughes (South Dakota politician), American politician ==Military==