2012 In April, Smith won the US F11, defeating
Pedro Zerbini 6–2, 6–0 in the final. In July 2012, Smith won the Winnetka Challenger against
Ričardas Berankis 3–6, 6–3, 7–6 in the final. This was his first Challenger title, which he also had to qualify.
2013 In 2013, Smith competed mostly on the Challenger Tour. His first title came on 25 August at the Canada F6, where he defeated Ante Pavić 3–6, 6–4, 6–3 in the final. Smith also enjoyed a successful week in
Tiburon; with his quarterfinal finish he vaulted 15 spots to a new career-high ranking of No.208.
2014 Smith made the second round of
qualifying before losing to
Denis Kudla in straight sets. He qualified for
Indian Wells but lost in round one to
Robin Haase. Smith made the final of the
Taipei Challenger, losing to
Gilles Müller 3–6, 3–6. This increased his ranking to a career high of No. 181. He lost in the first round of
Wimbledon qualifying to
Farrukh Dustov. In the two
Traralgon ATP Challenger events, Smith lost in the semifinal to
Bradley Klahn in
1 and in the quarterfinal to
Ben Mitchell in
2. In December, Smith narrowly missed out on a wildcard into the
2015 Australian Open, losing in the final of the
Australian play off to
Jordan Thompson 1–6, 3–6, 6–1, 7–6, 7–9. Smith ended 2014 with a ranking of 201.
2015: First ATP tour singles win and semifinal, Career-high ranking in singles Smith commenced 2015 at the inaugural
Onkaparina Challenger, but lost in round one to
Marcos Baghdatis. He was eliminated in the second round of
qualifying for the Australian Open to compatriot
Omar Jasika 7–6, 3–6, 10–12. In February, Smith headed to USA where he made the quarter final of the
Dallas Challenger. He then played and qualified for the
Delray Beach main draw. This was the fourth ATP World Tour event for which he has qualified. He drew No.1 seed
Kevin Anderson and lost in round one. Smith lost in round one of qualifying for
Indian Wells before returning to the Challenger Tour, where he won the
Drummondville Challenger over crowd favourite,
Frank Dancevic. This was his second career Challenger title and first since 2012. This win gave Smith a near career high of 163. In June, Smith secured his first Grand Slam main-draw entry via qualifying for the first time in his career at
Wimbledon. He lost in round one to
Kenny de Schepper in five sets, despite leading 2–0 sets. In July, Smith entered the
Newport Championships and defeated compatriot and third seed
Bernard Tomic in the first one, his first win on the
ATP World Tour on the way to the semifinal where he lost to eventual champion
Rajeev Ram. At the
US Open, Smith qualified before losing to
Mikhail Youzhny in round one. He reached a career-high ranking of No. 108 on 28 September 2015. Smith ended 2015 with a singles ranking of No. 129.
2016: Loss of form Smith began 2016 with a wildcard into the
2016 Brisbane International. He lost in round one. Smith made the second round of
qualifying at the Australian Open. In February, Smith qualified for
Delray and defeated world No. 26 and No. 3 seed
Ivo Karlović in round one. He lost to
Juan Martín del Potro in round two. He lost in the qualifying rounds of
Mexican Open,
Indian Wells and
Miami Masters. In April and May, Smith returned to the Challenger Circuit across Asia and Europe with limited success. In June, Smith lost in round one of
Wimbledon qualifying. In July, Smith defeated compatriot
Jordan Thompson in the first round of the
Hall of Fame Tennis Championship, but lost to
Marco Chiudinelli in round two. Smith lost in round one of
US Open qualifying before returning to the Challenger Tour in USA and Australia in September, October and November. Smith ended 2016 with a singles ranking of No. 226.
2017: First Grand Slam doubles quarterfinal Smith began 2017 narrowly missing out on qualifying for
2017 Brisbane International and
2017 Australian Open, before playing a number of Challengers in North America. His best result being a semi-final result at
Drummondville in March. In April, Smith travelled to Europe and lost in the first round of qualifying for the
2017 French Open and in June at the
Surbiton Challenger before qualifying for and making the quarterfinals of the
Nottingham Challenger. At
Wimbledon, Smith lost in the last round of qualifying, 10–12 in the fifth set. In August, Smith qualified for the
Cincinnati Masters but lost to
Richard Gasquet in round one. In September, Smith reached the doubles quarterfinals
2017 US Open partnering
Nicholas Monroe.
2018: First ATP World Tour doubles title Smith commenced the season qualifying for the
2018 Brisbane International. He lost in round one to
Mischa Zverev. Smith lost in the final round of
qualifying for the Australian Open. In March, Smith travelled to the U.S. and played on the Challenger Tour, reaching the final of the
León Challenger in Mexico. In May, Smith lost in the
qualifying for the French Open. In June, Smith qualified for and lost in round one of
2018 Wimbledon Championships. In July, Smith won his first
ATP World Tour doubles title in
Atlanta Open partnering again with American
Nicholas Monroe with whom he also reached earlier in February the final at the
2018 Delray Beach Open. Smith competed on the Challenger Tour for the rest of 2018 with limited success.
2019: Australian Open mixed doubles final In January 2019 John-Patrick Smith alongside fellow Australian
Astra Sharma reached the final of the
Australian Open mixed doubles. The most notable of their victories on this run came against second seeds
Bruno Soares and
Nicole Melichar in straight sets, before eventually losing 6–7, 1–6 to
Barbora Krejčíková and
Rajeev Ram in the final. John continued his form in men's doubles later in the year, making nine Challenger finals and winning the
2019 Challenger Eckental and
2019 Puerto Vallarta Open. In December 2019, Smith won the
Australian Wildcard Playoff to earn direct entry in singles into the
2020 Australian Open.
2020–2021: Second Grand Slam doubles quarterfinal At the
2020 Australian Open he lost in the first round to
Guido Pella. In the
mixed doubles, he partnered again with
Astra Sharma, and they reached the semifinals in Melbourne. The following year, he reached the quarterfinals in doubles as a wildcard at the
2021 Australian Open partnering fellow Australian
Matthew Ebden, his best showing at this major and only his second quarterfinal in doubles in his career.
2025: Australian Open mixed doubles final Partnering
Kimberly Birrell, Smith reached the mixed doubles final at the
Australian Open, losing to
John Peers and
Olivia Gadecki. ==Significant finals==