During the Bush War Msika was elected as National Treasurer of the African National Congress in 1957; it was subsequently banned, at which point Msika became Secretary for Youth in the
Zimbabwe African People's Union (ZAPU), its successor organisation. As a result of his political activities, he was detained at Khami Maximum Security, Selukwe and Marandellas prisons from 1959 to 1961. He joined the National Democratic Party in 1961 and was elected a councillor. and was detained at
Gonakudzingwa Restriction Camp. In 1979, Msika was a member of the delegation to the
Lancaster House Agreement that forged independence for Zimbabwe. He was dismissed from the government in 1982, On 5 March 2005, Msika was taken into hospital after collapsing at home, apparently having suffered a stroke and a blood clot in his head. He did not run in the
March 2005 parliamentary election, but Mugabe appointed him to one of the thirty unelected seats in the House of Assembly. He also did not run in the
March 2008 parliamentary election, but was appointed to the Senate by Mugabe on 25 August 2008. He was then sworn in again as Vice-President by Mugabe on 13 October 2008, together with
Joyce Mujuru. In January 2009, when Mugabe went on his customary annual leave, Msika became Acting President. Msika became ill while attending a regional summit in June 2009, reportedly due to a stroke, and was treated at a South African hospital. He subsequently died at the West End Hospital in
Harare on 4 August 2009 Later in the day, the ZANU-PF Politburo met and agreed to confer upon Msika the status of national hero; it also agreed that he would be buried at
National Heroes' Acre. At the time of his death, Msika was the Second Secretary of ZANU-PF. Msika's funeral was held on 10 August, thereby coinciding with National Heroes Day. President Mugabe, Prime Minister
Morgan Tsvangirai, and Deputy Prime Ministers
Thokozani Khupe and
Arthur Mutambara were all present for the funeral, at which Msika was buried with full military honours; various high-ranking regional officials, including South African Deputy President
Kgalema Motlanthe, were also present. ==Disagreements with Mugabe==