She was only daughter of Thomas and Anne Curzon of
Croxall Hall in
Staffordshire. Her maternal grandfather was Sir John Aston of
Tixall. She first married Sir George Appleby of
Appleby in Leicestershire and they had two sons. Her husband died in 1547 at the
Battle of Pinkie. She then married Thomas Lewis of
Mancetter on 10 September 1547. She was a Catholic, but she began to question her faith, according to the partisan martyrologist
John Foxe, after the martyrdom of
Lawrence Saunders on 8 February 1555. Her move to being a Protestant was led by the brother of another martyr,
Robert Glover, who died the same year. Her previous devotion to Catholicism was replaced by "irreverent behaviour in church" which came to the notice of
Ralph Baines, the
Bishop of Lichfield. Lewis spent a year in jail before she was taken, with the comfort of the priest
Augustine Bernher, to be burnt at Lichfield on 18 December 1557. ==Legacy==