Early work (1970s–2000s) Wachtel first exhibited at
MoMA PS1, presenting a film and audio installation,
Follow the Leader (1979). The piece combined two Super 8 films, one of couples combing one another's hair on a bluff and another of a hand assembling a face from vinyl cutouts. These films were set to fragmented soap opera dialogue. Wachtel later described this structure as a "linear collage," built on rhythm and juxtaposition rather than narrative. In 1984, she had her first solo exhibition at Gallery Nature Morte where she showed a series of vertical paintings combining images lifted from folk art and pop culture. According to Bob Nickas, "Wachtel's major statement from the mid-'80s is her series
Emotional Appeal (1986), a dozen paintings that alternate in their hanging from cartoon to primitive figures."
Later work (2010s–present) In 2013, a solo show at Vilma Gold in London,
Post Culture served as a miniature survey of her career. In 2014, the
Cleveland Museum of Art organized her second solo institutional show at the museum's Transformer Station. A catalogue was published by
Yale University Press, with essays by Reto Thüring and Quinn Latimer. One painting contrasted Kim Jong-un with South Korean pop star Psy, whose "Gangnam Style" was then the most-viewed video in YouTube history; another placed a silkscreened Hillary Clinton alongside painted prehistoric Venus sculptures. Due to the
COVID-19 pandemic in 2020, Wachtel began making short videos, pulling clips from television and commercials into looped sequences featured in the online exhibition
Passing Time. In early 2021, Wachtel had a solo exhibition,
Fulfillment, at Helena Anrather in New York. Writing in the
New York Times, Will Heinrich described Wachtel's paintings as portraying "an alternate reality, one in which America's disintegrating public discourse is replaced by the narrow but reliable certainties of art." In 2022, she presented
Believe at Super Dakota in Brussels, including the painting "Airport", a large-scale multi-panel work depicting an airport terminal filled with directional signage and embedded stock-image watermarks. ==Exhibitions and collections==