MAMCO's collection comprises almost 6,000 works created between the second half of the 20th century and the beginning of the 21st century, with about half of the holdings available through the museum's online catalogue. The museum has particularly strong collection of works by
Siah Armajani,
John M Armleder, Tobias Kaspar,
Guy de Cointet,
Sylvie Fleury,
Olivier Mosset,
Steven Parrino,
Philippe Thomas and
Franz Erhard Walther. It also includes substantial groups of works by
Louise Lawler,
Christian Marclay,
Maurizio Nannucci,
Nam June Paik and
General Idea, alongside works by
Helen Frankenthaler,
Gordon Matta-Clark and
Frank Stella. The collection has grown mainly through donations, bequests and targeted acquisitions rather than through a standing acquisitions budget. Since 2017, MAMCO has also expanded its holdings through its
In Course of Acquisition project at artgenève, which the museum said had brought around sixty works into the collection by 2026. ==Directors==