McElrath's scientific interests include understanding the
human immune system responses that regulate and prevent HIV-1 infection. She continues to be involved in a global initiative to develop an HIV-1 vaccine and research aiming to identify innate and mucosal immune defences generated following vaccination. McElrath has contributed to numerous integrated programs at the national and international levels to advance a coordinated effort to curb the
HIV epidemic through prevention efforts. These include the
HIV Vaccine Trials Network, the
Gates Foundation Innate Immunity Consortium (PI), the
Microbicide Trials Network (director, Immunology Core), and the Seattle Vaccine Trials Unit (PI). Research in the McElrath Laboratory at Fred Hutchinson Cancer Center includes studying how
T cell memory is induced by natural infection and
immunization. McElrath and her team are also working to identify the properties of T cells that confer containment or eradication of HIV-1. Their studies span a wide array of immunologic investigations in persons who experience unusual control of HIV-1 infection, including individuals with newly diagnosed infection, those with long-term non-progressive disease who control infection for more than a decade without antiretroviral treatment, and people repeatedly exposed but not infected. These clinical cohorts have been assembled for
longitudinal studies in Seattle, as well as
South Africa and
Uganda, two nations where the HIV epidemic is widespread. On December 1, 2015, the work of McElrath and HTVN scientists investigating a vaccine to potentially halt HIV and AIDS was highlighted in an HBO/VICE special report titled "Countdown to Zero." == Recognition ==