Main •
Rebecca Ferguson as Juliette Nichols, an engineer who works on the generators in the lowest levels of the Silo •
Amelie Child-Villiers portrays a young Juliette •
Rashida Jones as Allison Becker (season 1), a woman who works in the
IT Department in the Silo and is married to Holston. During their attempts to conceive a child, she becomes suspicious of the Silo's true history and how it is governed •
David Oyelowo as Holston Becker (season 1), the devoted husband of Allison and the
sheriff of the Silo •
Common as Robert Sims, the head of security for Judicial, who maintains order within the Silo •
Tim Robbins as Bernard Holland, the strict head of the IT Department in the Silo •
Harriet Walter as Martha Walker, an electrical engineer with severe
agoraphobia who runs a workshop in the lower levels of the Silo and acts as a parental figure to Juliette •
Avi Nash as Lukas Kyle, a systems analyst in the IT Department who is curious about the world outside the Silo •
Rick Gomez as Patrick Kennedy, a maintenance worker and former smuggler of "relics", objects from the world before the Silo •
Chinaza Uche as Paul Billings, the newly assigned chief deputy and a former Judicial administrator who is afflicted with the "Syndrome", a medical condition that causes
tremors •
Shane McRae as Knox (season 2; recurring season 1), the head of the Mechanical level in the Silo and Juliette's boss • Charlie Coombes portrays a young Knox • Remmie Milner as Shirley Campbell (season 2; recurring season 1), an engineer in Mechanical who is Juliette's closest friend and colleague • Ida Brooke portrays a young Shirley •
Alexandria Riley as Camille Sims (season 2; guest season 1), Robert's wife, the mother of their son, and a former raider •
Clare Perkins as Carla McLain (season 2; guest season 1), Walker's ex-wife and the head of the supply department •
Billy Postlethwaite as Hank (season 2; recurring season 1), a deputy who works in the lower levels •
Steve Zahn as Jimmy Conroy / "Solo" (season 2), the only living survivor of the rebellion in Silo 17 • Cameron Bell portrays a young Jimmy •
Ashley Zukerman as Daniel (season 3; guest season 2), a United States congressman during the time before the Silos were created •
Jessica Henwick as Helen (season 3; guest season 2), an inquisitive journalist based in Washington, D.C.
Recurring •
Will Patton as Samuel "Sam" Marnes (season 1), a deputy who works under Sheriff Holston and closely with Mayor Jahns •
Ferdinand Kingsley as George Wilkins (season 1), a
computer geek who runs a repair shop. He seeks out Allison for her help to uncover the secrets of the Silo •
Chipo Chung as Sandy, a
clerical worker in the sheriff's department • Matt Gomez Hidaka as Terry Cooper (season 1; guest season 2), a rookie engineer in the lower levels and Juliette's
shadow • Olatunji Ayofe as Teddy, a worker in Mechanical and one of Juliette's colleagues •
Iain Glen as Dr. Pete Nichols (seasons 1–2), an
obstetrician and the father of Juliette, from whom he has been estranged since she was a teenager • Angela Yeoh as Molly Karins, a deputy who works in the mid-levels •
Tanya Moodie as Judge Mary Meadows (seasons 1–2), the head of Judicial who enforces the Pact, a list of rules that all Silo residents must follow • Caitlin Zoz as Kathleen Billings, Paul's wife and the mother of their daughter •
Akie Kotabe as Diego, a Watcher monitoring the Silo • Christian Ochoa as Rick Amundsen (season 2; guest season 1), a high-ranking raider, a group of armed enforcers working for Sims
Guest •
Geraldine James as Ruth Jahns (season 1), the elected mayor of the Silo •
Sophie Thompson as Gloria Hildebrandt (season 1), a paranoid woman who became the Silo's fertility counselor after failing to conceive a child herself •
Sienna Guillory as Hanna Nichols (season 1), a surgeon and the deceased mother of Juliette •
Henry Garrett as Douglas Trumbull (season 1), an enforcer for Judicial who is loyal to Sims •
Sonita Henry as Regina Jackson (season 1), a former relic dealer and lover of George •
Will Merrick as Danny (season 1), a criminal hacker who disrupts the IT Department's security network •
Ross McCall as the Silo 17 Sheriff (season 2), the leader of the rebellion in Silo 17 • Nick Haverson as Russell Conroy (season 2), the head of the IT Department in Silo 17 and Solo's father • Imogen Butler-Cole as Gwen Conroy (season 2), Solo's mother •
Pippa Winslow as Gladys (season 2), a worker in Mechanical during Juliette's childhood •
George Robinson as Mark Chambers (season 2), the overseer of a manufacturing workshop • Sacharissa Claxton as Frances Boyer (season 2), Patrick's niece • Georgina Sadler as Audrey (season 2), the leader of a group of young orphaned survivors in Silo 17 • Orlando Norman as Rick (season 2), Audrey's boyfriend and the father of their two children • Sara Hazemi as Hope / "Eater" (season 2), the outcast of Audrey's group •
Stuart Milligan as Terrance Penbrook (season 2), a descendant of Salvador Quinn, the former head of IT over 140 years prior •
Lolita Chakrabarti as Lukas' mother (season 2) ==Episodes==