Lachman first filmed an
ad in Australia for
Wanadoo, which aired in the United Kingdom. In 2005, she joined the cast of the Australian soap opera
Neighbours as
Katya Kinski. She had auditioned for the role of
Elle Robinson, but the producers decided to create the part of Katya for her. Lachman played a small role in the feature film
Aquamarine. After she finished shooting the role of Aaren in the film
Bled, Lachman joined the cast of the film
Aztec Rex in Hawaii. In an interview with
The Soap Show, Lachman said she had appeared on the
BBC television show
Ready Steady Cook while visiting England in late 2006. In the interview, she explained that she was in
Los Angeles to advance her acting career, but said she would love to work in the UK and Australia. On 26 March 2008, it was announced that Lachman would portray
Sierra in the television series
Dollhouse, created by
Joss Whedon. In an interview with ScifiNow in 2009, Lachman responded to the rumour that she would star in an upcoming television show based on
Star Wars by saying, "I am a huge
George Lucas fan. I love those movies and it would be a dream come true—I'd love to do it, it would be incredible." She was named one of the 100 hottest women on screen for 2009, by the lesbian media site
AfterEllen.com. "What a privilege to be there," she said. She guest starred as an insurance agent/street racer on
NCIS: Los Angeles. She also appeared as Amy Hanamoa, the widow of a murdered police officer, in an episode of
Hawaii Five-0. Lachman made a guest appearance in an episode of the
Doctor Who spin-off
Torchwood, for its fourth series
Torchwood: Miracle Day. Additionally, in 2011 it was announced in
Variety that Lachman would be joining the cast of
Being Human as a series regular. In 2012, it was announced Lachman would be joining the
Shawn Ryan–driven pilot
Last Resort for ABC, and she subsequently appeared as a main character during the show's 13-episode run. She also guest starred in the second season of the
Jane Espenson scripted web series,
Husbands. Between 2010 and 2013, while working on other productions, Lachman and her close friend Anton King produced
Lust for Love. King wrote the script in 2010 and used
Kickstarter to raise funds to make the movie. The initial goal was to raise US$70,000; however, when the deadline was reached on 11 November 2011 more than 1,500 people had pledged money, with a final figure of US$101,030. as director of photography. In 2014, Lachman began shooting in Canada, where she joined the cast of
The 100 in the role of Anya and had a recurring role on
ABC's
Agents of S.H.I.E.L.D. On 11 June 2015, a new movie called
Too Late, starring Lachman, was released during the
Los Angeles Film Festival. On 22 October 2015, it was announced that Lachman landed a recurring role on the third season of
Michael Bay's action-adventure
TNT series
The Last Ship. Lachman had been cast as Jesse, a helicopter pilot who lives
off-the-grid. She starred as Reileen Kawahara in
Netflix's original television series,
Altered Carbon, an adaptation of the
2002 novel of the same name by
Richard K. Morgan. The first season was released on 2 February 2018. Also starting in 2018, Lachman began a recurring role as Frankie on
Animal Kingdom during its third season. In 2020, she returned for small story arcs on
Agents of S.H.I.E.L.D. and
Altered Carbon, and she also appeared in the film
Bad Therapy. In 2022, Lachman joined the main cast of
Severance, which premiered on
Apple TV+. She appeared as Ms. Casey, a wellness counselor. The series received acclaim from critics and audiences, with Lachman being nominated for Best Supporting Actress in a Streaming Series, Drama at the
2nd Hollywood Critics Association TV Awards. Soon after she appeared as antagonist Soyona Santos in the 2022 film
Jurassic World Dominion. Lachman was then announced as the titular character in
Steven Brand's noir thriller
Joe Baby. In 2024, she was announced to star in the dark thriller,
Unholy Night, alongside
Ed Speleers and
Ed Westwick. She also reprised her role from
Jurassic World Dominion in
Jurassic World: Chaos Theory. In November 2025, it was revealed that Dichen Lachman joined the cast of
The Legend of Zelda live-action film. ==Personal life==