Pickett made his
AFL debut in Round 1,
2020 against at
Perth Stadium. He played 14 games in his debut season earning a
Rising Star nomination in round 11 following Melbourne's 57-point win over , when Pickett kicked a goal and had 12 possessions. In June 2020, Pickett was suspended for one match for breaching AFL COVID-19 protocols after he and teammate
Charlie Spargo travelled via an
Uber to an unauthorised house for a gathering. In 2021, Pickett played all 25 of Melbourne's games through their finals campaign. Pickett earned a premiership medal as Melbourne won the
Grand Final, though he was held to four possessions and three tackles in the game. In September of
2023, Pickett was handed a one-match ban by the Match Review Officer's verdict after a head-high hit on Patrick Cripps that left the superstar Carlton captain bloodied. Melbourne went on to lose that match, giving them a fourth consecutive finals loss. In
2024, Pickett received a third suspension in just over a year for head high contact, this time against
Jake Soligo of . Prior to the
2025 season, Pickett played in the
Indigenous All-Stars representative match against . He kicked a goal in the 43-point win. Reaching career-best form in
2025, including five goals and 24 disposals against , rumours began to spread that Pickett would request a move to a
South Australian or
Western Australian club in the upcoming off-season. However, in June 2025, Pickett signed a seven year contract extension, keeping him at the club for nine years and a reported
$12.5 million dollar salary over that period, breaking records across the league. ==Personal life==