Pre-draft Hamilton declared for the
2022 NFL draft following the 2021 season, where he was considered by some to be its best prospect.
2022 season Hamilton was selected by the
Baltimore Ravens in the first round (14th overall) of the draft. He signed his rookie contract on June 7, 2022. Hamilton entered the 2022 season as the Ravens second-string safety. In his debut in Week 1 against the
New York Jets, Hamilton had three solo tackles in a 24–9 win. In Week 3 against the
New England Patriots, Hamilton forced the first fumble of his career. He also had three combined tackles (two solo) in a 37–26 win. Hamilton made his first sack and tackle for loss in a 23–20 win against the
Cleveland Browns in Week 7. In Week 11 against the
Carolina Panthers, Hamilton reinjured the same knee he injured in college. He was marked as inactive for their Week 12 game against
Jacksonville Jaguars. Hamilton played in 16 of the 17 games while starting in four. He finished the season with 62 total tackles (46 solo), two sacks, five pass deflections, and a forced fumble. Following the season, he was named to the
PFWA All-Rookie Team. In the
AFC Wild Card Game against the
Cincinnati Bengals, Hamilton had nine total tackles (five solo) as well as a forced and recovered fumble in a 24–17 loss.
2023 season Hamilton was named the starting
strong safety for the 2023 season. In Week 3 against the
Indianapolis Colts, Hamilton tied the NFL and broke the franchise record for sacks in the first half of a game with three. He also had nine tackles (seven solo), two tackles for loss, a forced fumble, and a pass deflection. However, the Ravens would end up losing 19–22. In their Week 4 game against the Browns, Hamilton caught the first interception of his NFL career while also recording five solo tackles and a pass deflection. This would seal their 28–3 victory. In Week 6 against the
Tennessee Titans, Hamilton was
ejected for
targeting after hitting
wide receiver Chris Moore in the head while he was defenseless. He was fined $20,524 for the hit. In Week 10 against the Browns, Hamilton scored his first NFL touchdown when he tipped a pass from
Deshaun Watson to himself to score an 18-yard pick-six to give the Ravens a 7–0 lead on the second play from scrimmage. However, the Ravens would end up losing 31–33. In Week 14 against the
Los Angeles Rams, Hamilton bumped knees with wide receiver
Puka Nacua, sidelining him for the remainder of the contest, which ended in 37–31 overtime victory. On
Christmas Day in Week 16 against the
San Francisco 49ers, Hamilton recorded two interceptions as the Ravens won 33–19. During the game, however, Hamilton again injured his knee in the fourth quarter and sat out the remainder of the win. Despite not finishing the game, he was named
AFC Defensive Player of the Week. Before the Ravens' Week 17 game against the
Miami Dolphins, Hamilton was ruled out. Before Week 18, Hamilton was named to the
2023 AFC Pro Bowl Team. Hamilton played in 15 games during the 2023 season and started in all 15 of them. He tallied 81 total tackles (63 solo), 3.0 sacks, ten tackles for loss, 13 pass deflections, four interceptions, and a defensive touchdown.
2024 season Hamilton was again named as the starting safety for 2024 season. Uncharacteristically, the Ravens had one of the worst passing defenses in the NFL at the beginning of the season, although this was due to the poor play of
Eddie Jackson and
Marcus Williams, which put more stress on Hamilton. Both players were eventually replaced by
Ar'Darius Washington, who solidified the defense into a much better unit. Hamilton had a solid season, finishing with a career-high 107 combined tackles, 2.0 sacks, an interception, nine pass deflections, two forced fumbles, and a fumble recovery. He was named to his second consecutive Pro Bowl on January 2, 2025.
2025 season On April 30, 2025, the Ravens picked up the fifth-year option on Hamilton's contract. On August 27, he signed a four-year, $100.4 million contract extension that included $82 million guaranteed, the largest contract for a safety in NFL history. Hamilton was selected to his third consecutive Pro Bowl in December 2025. Pro Football Focus ranked him 9th in their list of the top 101 players of 2025. ==Career statistics==