McNeill–Maxie–McLain, Mississippi This strong and long-tracked EF3 tornado touched down in
Pearl River County, just southwest of
McNeill where it downed several trees at EF0 to EF1 intensity along Harris Road. It then rapidly intensified to high-end EF2 strength as it impacted the western edge of McNeill, where many trees were snapped and multiple houses were heavily damaged or destroyed. A small house along Joe Smith Road was left with only a few walls standing, and an elderly woman was critically injured inside. A nearby brick house had its roof torn off. A strong
velocity couplet and
debris ball became visible on
Doppler weather radar by this time. The tornado reached its peak strength of EF3 as it crossed Stones Chapel Road at the north edge of town, where it destroyed a single-story brick triplex, with only two interior walls left standing. A nearby house was heavily damaged at EF2 strength, and a few others sustained lesser damage in the area. One house in McNeill that was damaged beyond repair had survived effects from both
Hurricane Camille and
Hurricane Katrina. It then weakened back to EF2 strength as it crossed
US 11, snapping numerous trees and tearing the roofs off of some houses. The tornado weakened further and crossed
I-59, moving through unpopulated rural areas southeast of
Poplarville, causing EF0 to EF1 tree and outbuilding damage. The tornado then struck a house at EF1 strength near the
Stone County line, causing heavy roof damage. Eight people were injured in Pearl River County, 22 houses were destroyed or damaged beyond repair, eight had major damage, 16 had minor damage, and an additional nine were affected in some way. The tornado strengthened to EF2 intensity again as it entered Stone County west of
Texas, and caused significant damage to a few houses. Numerous pine trees were snapped at a campground in this area, and a mobile house and several more trees were downed before the tornado moved out of Stone County. The tornado then moved into
Forrest County and produced high-end EF2 damage as it passed near the small community of
Maxie, where numerous trees and power lines were downed, two double-wide mobile homes were completely destroyed, a pickup truck was rolled, and a camper was thrown about . Two additional double-wide mobile homes were severely damaged, a single-wide mobile home also sustained major damage, and a falling tree demolished a travel trailer. Four people were injured in Forrest County. The tornado momentarily weakened to EF1 intensity as it crossed into
Perry County and moved through portions of the
DeSoto National Forest, downing many trees. A house sustained considerable roof and window damage, outbuildings were destroyed, and two cars were moved along this segment of the path. It quickly regained EF2 status as it crossed
MS 29 and snapped several wooden electrical transmission poles. The tornado then destroyed a mobile home and a hunting camp before weakening back to EF1 status, damaging a few homes, and downing many more trees. The path length through Perry County was about . The tornado continued northward and inflicted EF2 damage to several homes and
Trinity Episcopal Church. At the church, part of a new slate roof was blown into the parking lot and a large portion of an exterior brick wall was knocked out, leaving a portion of the building visible from the outside. Homes in surrounding neighborhoods had their roofs torn off, large trees were snapped and uprooted, and gas leaks were reported in the area. The tornado widened to its widest point of along this portion of the path. The tornado continued to the north at EF2 intensity, ripping roofs off of homes as it crossed Springhill Avenue. By this point, a
tornado emergency was declared for areas of Downtown
Mobile at 2300 UTC (5:00 p.m. CST) as the large tornado approached those areas, stating Midtown Mobile, Downtown Mobile, and
Prichard, Alabama as potentially affected areas. The tornado then weakened slightly to high-end EF1 strength, damaged several more homes, and blew out windows at Mobile Infirmary Medical Center, a hospital of more than 500 beds. Automobiles in the parking lot at the hospital were damaged, with one being flipped. It continued through the Allenville neighborhood, across
I-165 and into Prichard. Damage along this segment of the path ranged from mid-range to high-end EF1, as multiple small homes and apartment buildings were damaged, some of which sustained roof loss. It also tossed several shipping containers and damaged a warehouse facility, before producing additional minor EF0 damage in the Plateau neighborhood of Prichard and then lifting. Many trees and power lines were downed along the path, which totaled . Several people suffered minor injuries. The tornado followed a path just east of the weaker EF1
December 20 tornado, which also impacted Mobile. ==Impact==