Chemistry and physics •
Lattice energy, the energy of formation of a crystal from infinitely-separated ions •
Lewis number, a dimensionless number ratio in physics •
Ligand efficiency, a measure of the binding energy of a ligand to its binding partner
Computing •
Linear Executable, an OS/2 file format •
LE (text editor), a simple text editor for unix-like operating systems •
Let's Encrypt, a non-profit certification authority •
Little-endian, a system that stores the least-significant byte at the smallest address
Other uses in science •
Lunar eclipse, in astronomy •
Lupus erythematosus, autoimmune diseases ==Transportation==