The protein is 82.3 kDa and has a 40 amino acid long
LEM domain located at its amino-terminal region. In its carboxyl end it has a
RNA recognition motif (RRM). The LEM domain is also common to two other integral proteins of the INM:
lamina-associated polypeptide 2 (LAP2) and
emerin. The LEM segment enables LEMD3 to attach to the
barrier-to-autointegration factor (BAF), and therefore, indirectly interact with the
chromatin. LEMD3 also has several implications in regulating the
cytokine family such as the
transforming growth factor beta (TGF-β) and
bone morphogenic protein (BMPs). The RRM domain in its carboxylic region attaches to the
SMAD (protein) proteins, which is involved in mediating TGF-β
cellular signalling. Consequently, LEMD3 indirectly regulates downstream genes. LEMD3 seems to play an important role in regulating the expression of several fundamental genes. ==LEMD3 and disease==