Early career Making his MMA debut at FCC 15, he faced Martin Fouda and went on to defeat him via unanimous decision. Murphy would go on to defeat Tyler Thomas at Tanko FC 3, Jamie Lee at FCC 18, Nathan Thompson at FCC 19, Terry Doyle at FightStar Championship 14, all via first round TKO. He would go on to defeat his next two opponents via unanimous decision; James McErlean at Evolution Of Combat Fight Night 2 and Anton De Paepe at Celtic Gladiator 22. For his final appearance in the UK regional scene, Murphy won the FCC Featherweight Championship at FCC 23 against Manolo Schianna via TKO in the first round.
Ultimate Fighting Championship Murphy made his UFC debut against
Zubaira Tukhugov on 7 September 2019 at
UFC 242. The back-and-forth fight ended in a split draw with one judge assigning each fighter a 29–28 win and the third seeing it as a 28–28 draw. Murphy faced
Ricardo Ramos on 16 July 2020 at
UFC on ESPN 13. He won the fight via technical knockout in round one, earning himself a Performance of the Night bonus. After his second fight in the promotion, Murphy renewed his contract with the UFC. Murphy faced
Douglas Silva de Andrade on 20 January 2021 at
UFC on ESPN 20. He won the bout via unanimous decision. Murphy was scheduled to face
Charles Jourdain on 4 September 2021 at
UFC Fight Night 191. However, Murphy was pulled from the event due to visa issues, and he was replaced by
Julian Erosa. Replacing an injured
Tristan Connelly, Murphy stepped in on short notice against
Makwan Amirkhani at
UFC 267 on 30 October 2021. Murphy won the bout via knockout early in the second round. Murphy was scheduled to face
Nate Landwehr on 26 March 2022 at
UFC on ESPN 33. However, Murphy withdrew from the bout for undisclosed reasons and was replaced by David Onama. Murphy was scheduled to face
Nathaniel Wood on 18 March 2023 at
UFC 286. However, Wood was forced to withdraw from the event due to leg injury and was replaced by UFC newcomer Gabriel Santos. Murphy won the fight via split decision. Murphy faced
Joshua Culibao on 22 July 2023 at
UFC Fight Night 224. He won the fight via unanimous decision. Murphy was scheduled to face
Dan Ige on 10 February 2024 at
UFC Fight Night 236. However, Murphy pulled out in mid-January due to an undisclosed injury. Murphy faced
Edson Barboza on 18 May 2024 at
UFC Fight Night 241. He won the fight by unanimous decision. This fight earned him the
Fight of the Night award. Murphy faced
Dan Ige on 26 October 2024 at
UFC 308. He won the bout via unanimous decision. Murphy faced former interim
UFC Featherweight Championship challenger
Josh Emmett on 5 April 2025 in the main event at
UFC on ESPN 65. He won the fight by unanimous decision. Murphy faced
Aaron Pico on 16 August 2025 in the co-main event of
UFC 319. He won the fight via knockout with a spinning back elbow in round one. This win earned Murphy his second
Performance of the Night award. Murphy faced fellow undefeated contender
Movsar Evloev in the main event title eliminator bout on 21 March 2026, at
UFC Fight Night 270. Despite being the recipient of repeated groin strikes that resulted in a point deduction for Evloev in the fourth round, Murphy ultimately lost the fight by majority decision, marking the first defeat of his mixed martial arts career. 12 out of 17 media outlets scored the bout as a draw while the remaining five scored it for Murphy. ==Personal life==