A light heavyweight bout between former
KSW and
UFC Light Heavyweight Champion Jan Błachowicz and
Aleksandar Rakić was expected to serve as the event headliner. However, in late January, Błachowicz withdrew due to an injury and the bout was rescheduled for
UFC on ESPN 36. Instead, a heavyweight bout between
Curtis Blaydes and
Chris Daukaus headlined the event. A women's flyweight bout between
Joanne Wood and
Alexa Grasso was originally scheduled for
UFC Fight Night: Vieira vs. Tate, but Grasso pulled out due to injury and the pairing was scrapped. They were then rescheduled for this event. A welterweight bout between
Matt Brown and
Bryan Barberena was expected to take place at
UFC on ESPN: Font vs. Aldo in last December, but Brown was removed from the contest due to
testing positive for COVID-19. They instead met at this event. A bantamweight bout between
Montel Jackson and
Danaa Batgerel was scheduled for this event. However, Jackson had to pull out of the bout and was replaced by
Chris Gutiérrez. A women's strawweight bout between former
Invicta FC Atomweight Champion Michelle Waterson and
Amanda Ribas was expected to take place at this event. However, Waterson was forced to withdraw in early March due to an undisclosed injury and the bout was postponed to
UFC 274. At first, they were expected to meet at
UFC 257, but Waterson pulled out of that bout due to undisclosed reasons.
Lerone Murphy and
Nate Landwehr were expected to meet in a featherweight bout. However, Murphy withdrew from the bout due to undisclosed reasons and was replaced by David Onama. In turn, Landwehr had to pull out of the bout and the bout was scrapped. Undefeated middleweights Aliaskhab Khizriev and
Abusupiyan Magomedov were expected to meet at the event. However, Magomedov pulled out for unknown reasons and was replaced by Denis Tiuliulin. A featherweight bout between Tucker Lutz and
Seung Woo Choi was scheduled for the event. However, Choi was forced to withdraw from the event due to an undisclosed injury and the bout was scrapped. A heavyweight bout between
Aleksei Oleinik and
Ilir Latifi was expected to take place at event. However, the bout was canceled as Latifi withdrew on the day of the event due to illness. The pairing was rescheduled for two weeks later at
UFC 273. ==Results==