Main •
Sara Rue as Claudia "Claude" Casey, the quirky, sweet lead character. From Pittsburgh, Claude works as the executive assistant for GNB anchorman Will Butler. Initially insecure due to the fish out of water template she personifies, Claude gains confidence in herself and her abilities as the series progresses. •
Sherri Shepherd as Ramona Platt, a sassy co-worker and friend of Claude and Owen. She is sometimes bossy and obnoxious, but is still a loyal and caring friend. She dislikes both Kipp and Lydia. •
Andrea Parker as Lydia Weston, one of Claude's "frenemies". She is shallow, snobby, and professionally ambitious, although without noticeable work skills. Lydia finds Claude to be a hick and a walking fashion faux pas. Eventually, Lydia begins a relationship with Jeb Denton, and marries him in the season three finale. In season four, she becomes the producer of Jeb's news segment, and hires Claude as her assistant. •
Zachary Levi as Kipp Steadman, Claude's other frenemy and Lydia's best friend, eventually becomes Jeb Denton's assistant. He is shown to be arrogant, shallow, and snobby, but is more intelligent, and occasionally shows flashes of far more humanity than Lydia (seen in episodes such as
The Pimp Hat and
Why Are You Hurting Claude?). •
Andy Dick as Owen Kronsky, a seriously offbeat, sensitive, and sometimes clumsy office supply manager with GNB. •
Eric Roberts as Will Butler (seasons 1–3), Claude's charming, but vain boss, a well-known national news anchor. He is a womanizer with several ex-wives. Will unexpectedly (and offstage) quits the network at the start of season 4, forcing Claude to scramble for another position—working for Lydia. •
Will Sasso as Carl Monari (Seasons 2–4; recurring season 1), the cafeteria manager at GNB. He is a friend of Claude, Ramona, and Owen. He lives across the hall from Claude, and becomes her boyfriend in season four. •
Patrick Warburton as Jeb Denton (Seasons 2–4), Will Butler's co-anchor, and Lydia's boyfriend (later husband). Jeb is a mellow, funny, and ambitious news anchor, who is trying to climb the ladder at GNB. He is Kipp's boss, but rarely refers to him by name, mostly as "Secretary." His favorite food is Crab Cakes.
Recurring •
Josh Braaten as Charlie, Claude's boyfriend from the travel department (Seasons 1 & 3) •
William Ragsdale as Mitch Calgrove, a producer at GNB who Claude dates (Season 2) • John Eric Bentley as an assistant director who later returns as a director (Seasons 1 & 4) •
French Stewart as Gene Schmidtline, an employee at GNB who has a crush on Ramona (Seasons 2–3) •
Jenny McCarthy as Dani, Will's on-and-off girlfriend (Seasons 1-2) •
Diana-Maria Riva as Vivian, Carl's ex-girlfriend (Seasons 2–3) • Jonna Tamases as Irene, a co-worker at GNB who offers Claude a job (Season 4)
Guest stars •
Martin Mull as Buddy Casey, Claude's dad (Season 1) •
Cindy Williams as Joan Casey, Claude's mom (Season 1) •
Joanna Cassidy as Norma (Season 1) •
Michael Boatman as Ted Elliot, a director who employs Claude (Seasons 1 & 2) •
Trista Rehn as herself (Season 1) •
Richard Ruccolo as Bobby Casey, Claude's brother (Season 1) •
Barry Bostwick as Max Damarius (Season 1) •
Nicole Sullivan as Deirdre Bishop, Owen's love interest (Season 1) •
George Wyner as Alan Turnbach, head of GNB news (Seasons 1 & 4) •
Simon Helberg as Arthur (season 2) •
Randee Heller as Mrs. Ross (season 2) •
Gordon Clapp as Detective Martin (season 2) •
Pamela Anderson as Vicki Devorski (season 2) •
Bill Walton as himself (season 2) •
Joanna Kerns and
Valerie Harper as Judy and Judith, Owen's lesbian mothers. (seasons 2 & 3) •
Michael Angarano as George Denton, Jeb's son (seasons 2 & 3) •
Lesley Ann Warren as Diane Steadman, Kipp's mom (season 2) •
Brooke Burke as Nurse Benson (season 2) •
James Belushi as sandwich vendor Eddie Smirkoff (season 2) •
John McEnroe as himself (season 2) •
Tori Spelling as Roxanne Fiedler, Claude's childhood best friend. (season 2) •
Lucy Lawless as Tracy Fletcher (season 3) •
Richard Kind as Lance Corcoran (season 3) •
John Di Maggio as Bartender (season 3) •
David Cassidy as Vince (season 3) •
Paula Abdul as Kathleen (season 3) •
Kimberly Williams as Laura (season 3) •
Regis Philbin as Xin Xao Pi (season 3) •
Joan Rivers as Louise (season 3) •
Paul DiMeo,
Tracy Hutson &
Michael Moloney as themselves, the cast of
Extreme Makeover (season 3) •
Star Jones as Dr Curtis (season 3) •
Christopher Knight as Waiter (season 3) •
Joey McIntyre as Ethan (season 4) •
Tony Plana as The Owl Inspector (season 4) •
Natasha Alam as Daniella (season 3) == Episodes ==