Originally opened in 2001 at Seventh and College streets, the museum's previous exhibit was called "Cotton Fields to Skyscrapers: Charlotte and the Carolina Piedmont in the New South", and featured period displays that reflected regional history. The displays included a one-room
tenant farmer's house, a
cotton mill and mill house, an African-American hospital, an early
Belk department store, and a civil-rights era lunch counter. Changing exhibits focus on local culture, art and history. In 2019, the museum had an exhibit "The Legacy of Lynching: Confronting Racial Terror in America", prepared in collaboration with the
Equal Justice Initiative, who created the
National Memorial for Peace and Justice. Relocation was considered in 2020 because the site had no room for expansion and was worth $7.7 million according to county records. The
COVID-19 pandemic was one reason for considering more virtual options. On June 16, 2021, the museum announced it would sell the downtown location and look for a new home. This news comes as the museum adds virtual activities such as the digital walking tour starting in August 2021. These changes come with the help of a $600,000 grant from the
John S. and James L. Knight Foundation. In March 2022, the museum announced the sale of its building for $10.75 million to Vela Uptown LLC, which planned to build a high-rise apartment building at the location. The museum closed in May to prepare for the move. The Museum then opened at 401 S. Tryon in the 6000 square feet
Levine Center for the Arts at
Three Wells Fargo Center, a space donated by
Wells Fargo. Since then, the museum was closed again on May 4, 2025, and the museum is planning to move to a yet disclosed new location. ==Gallery==