Grant announced her turning professional in August 2021, ranked 4th in the
World Amateur Golf Ranking. In her first month as a professional, Grant claimed two successive second-place finishes on the
Ladies European Tour, at the
Skaftö Open and the
Creekhouse Ladies Open. In October she won her first tournament as a professional, the
Terre Blanche Ladies Open in France. In December 2021, she earned her
LPGA Tour card at the
LPGA Final Qualifying Tournament. In February 2022, Grant won two titles on the
Sunshine Ladies Tour in South Africa. In March, she won her first
Ladies European Tour title at the co-sanctioned the
Joburg Ladies Open. After a tie for 7th at the season-ending
Investec South African Women's Open she captured the Sunshine Ladies Tour's Order of Merit title, ahead of
Lee-Anne Pace. In June 2022, Grant became the first woman to win on the
European Tour, at the time named the DP World Tour, by winning the
Volvo Car Scandinavian Mixed at
Halmstad Golf Club in Sweden, a tournament with a field mixed of 78 women and 78 men, playing from different tees for the same title and the same prize money, but divided when counting for the women on the Ladies European Tour and for the men on the European Tour. Grant went into the final round with a two shot lead, and went on to score an 8-under-par 64 in the last round, and to win by nine strokes ahead of the nearest men and 14 strokes ahead of the nearest women. After finishing runner-up in 2020 and 2021, Grant won the 2022
Skaftö Open by one stroke ahead of
Lisa Pettersson. Grant played only six events in her rookie season on the
LPGA Tour in 2022, garnering four top-10 finishes in the process. Although accumulating enough points to qualify for the
CME Group Tour Championship, Grant did not participate in the tour's season-ending event due to her
COVID vaccination status. Grant said through a statement via her agent, "with travel restrictions to enter the U.S. still remaining, it is still not an option for me to play LPGA events in the U.S. This is the sole reason I am not playing the CME." In May 2023, travel restrictions to enter the U.S. were lifted, and Grant started playing LPGA Tour events in the U.S. In her fourth start on U.S. soil since the release, she captured her first LPGA Tour win in July 2023 at the
Dana Open. It was the 120th Swedish LPGA Tour win and she became the 14th Swedish LPGA Tour winner. On the same day as her triumph, a Swedish player won on the men's tour,
Vincent Norrman at the
Barbasol Championship on the
PGA Tour. In June 2024, Grant won on the
Volvo Car Scandinavian Mixed for a second time, after starting the final day 11 shots behind 54-hole leader
Sebastian Söderberg, achieving the biggest come back ever in a golf tournament. In November
2025, Grant captured her second title on the LPGA Tour, winning
The Annika. The tournament was hosted by Grant's fellow countrywomen Annika Sörenstam and marked the 125th win on the LPGA Tour by a Swedish player. It was the second time Grant won a tournamen hosted by Sörenstam as was the case with her triumph at the
2022 Scandinavian Mixed hosted by Annika. ==Awards, honors==