Holton was active in the Republican Party when it was weak in Virginia, being one of the leading Republicans who fought the
Byrd Organization during the four decades it dominated Virginia politics. In 1965, Holton ran for governor as the Republican candidate and was defeated by
Democrat Mills E. Godwin Jr. In 1969, Holton won 52.51% of the vote in the gubernatorial election, defeating Democrat
William C. Battle, Virginia Conservative Beverly B. McDowell, American Independent William A. Pennington, and Independent George R. Walker. He became the first Republican governor of Virginia since 1869. in 1971 In 1970, when
desegregation was an issue in Virginia, Holton voluntarily placed his children, including future First Lady Anne Holton, in the mostly-black
Richmond Public Schools, garnering much publicity. As governor, he increased employment of blacks and women in state government, created the
Virginia Governor's Schools Program in 1973, provided the first state funds for community mental health centers, and supported environmental efforts. A moderate Republican, Holton was against welcoming conservative Byrd Democrats into the
Virginia Republican Party. As the GOP moved increasingly rightward, it turned its back on Holton. When
Harry F. Byrd Jr. broke ranks with the increasingly liberal national Democrats and ran as an independent for
the Senate in 1970, Holton insisted on running a Republican candidate rather than endorsing Byrd. That eventually led to the nomination of
Ray Garland. Byrd went on to win the three-way election with an absolute majority. Holton also encouraged a moderate Republican to run in
the 1971 special election to choose a successor for deceased Lieutenant Governor
J. Sargeant Reynolds, an election that was won by another independent, populist
Henry Howell. As Virginia does not allow governors to serve consecutive terms, Holton was not eligible to run
in 1973, so Mills Godwin, the conservative former Democrat who had defeated Holton in the 1965 election, became the Republican nominee. Godwin had supported
massive resistance to
racial integration and had first identified himself as a Republican in his speech accepting the Virginia Republican convention's nomination for governor. ==Later life==