The hospital was founded on January 19, 1930, by the
Sisters of the Little Company of Mary and serves much of the southwest side of
Chicago. In the early 20th century, the hospital—which was then segregated—refused to allow Dr.
Arthur Falls Sr. to perform surgery on
Dorothy Day, which both she and Falls protested. The hospital eventually relented, though on paper listed Falls as an assisting surgeon to a White physician. The first-ever
kidney transplant was performed in Little Company of Mary Hospital in 1950 on a 44-year-old woman who had
polycystic kidney disease. On October 17, 2019,
OSF HealthCare signed a merger agreement with Little Company of Mary Hospital. The merger took place on February 1, 2020. ==Deaths==