•
Jake Arguelles, portrayed by
Tony Labrusca, is Malia's childhood best friend in LLU, Frederick and Veruska Arguelles' werewolf son, heir to head guardian post to succeed Malia. He is in love with Malia. He kills his mother, Veruska, when she becomes a hybrid. He now serves in the Waya Board. •
Beatrice "Betty" Torralba-Domingo, portrayed by
Gelli de Belen, is Tonio's sister, Tristan's and Apple's aunt. She is the first successful human who survives a vampire's bite with the virus/serum protocol formulated by Prof T. However, the effects are temporary. She marries Doc and is killed by Supremo's allies on her wedding day. •
Veruska Arguelles, portrayed by
Ina Raymundo, is Jake's werewolf mother who betrays Matteo and Lia and the LLU for her ambitions. Supremo turns her into a hybrid and releases her to kill other werewolves. She is captured by Jake and the LLU fail to figure out how to cure her hybrid condition. She asks for Malia's forgiveness before she dies. She was a member of the Waya Council. •
Frederick Arguelles, portrayed by
Victor Neri, is Jake’s werewolf father and LLU’s Head Guardian and Waya Council president with Malia as his future successor. He stayed in hiding with his family and surviving LLU members from Sandrino and his rebel vampires. He is against his wife’s ambitions for their son. Near the end of the massacre, he dies protecting his family and fellow werewolves and vampires from death. His death was avenged by Malia after she and Tristan killed Sandrino. •
Baristo Elizeo, portrayed by
Joross Gamboa, is the werewolf who saves young Malia after her parents are killed by Supremo. He raises Malia as her surrogate father, and is a core member of the LLU leadership and sits in the Waya council. He is killed by Sandrino after he tried to avenge Lia and Mateo by attacking him. He dies trying to protect Tristan's grandparents. His death was avenged by Malia after she and Tristan killed Sandrino. •
Gael Mercado, portrayed by Bryan Santos. In the
Imortal series, he chooses to become a vampire as an alternative to cancer. He is originally loyal to Magnus, but he switches his alliance to Mateo and Lia and fights against Lucas’ hybrid allies at the finale of
Imortal. In La Luna Sangre, he is among the core group of LLU senior leaders. In the new order, he is President and CEO of Waya Inc. He reprises his role from
Imortal. •
Catleya Del Luna, portrayed by
Sue Ramirez, a werewolf and Baristo and Lydia’s adoptive daughter. She is also an adoptive sister to Malia and the junior representative in LLU. She survived the massacre and stayed in keen sight with Malia, Gael, Baristo, Jake, and then eventually Veruska and Jethro. While battling Sandrino, she was captured and tortured. Due to her brutal injuries, she was sent to China for medical treatment. Her fate is left unknown though it was implied that Catleya healed and returned to the LLU. •
Lemuel Ruiz, portrayed by
Khalil Ramos, is a Filipino-American
DJ, who becomes a vampire as part of Supremo's plan to turn celebrities into vampire allies. Supremo's vampire servants think he cannot survive the transition from mortal to vampire, so they leave his body for dead. As a new vampire, he meets Malia who convinces him to choose the alternative of drinking animal blood instead of human blood. He becomes Malia's staunchest ally and LLU member and working in the Waya Corp. He is working on cure for vampirism. •
Lydia Samonte, portrayed by
Nikki Valdez, a strong vampire, key LLU member, and Mateo’s former guardian who entered a relationship with Baristo and became an adoptive mother to Malia and Catleya. She was killed by Sandrino during the massacre’s ending by buying Malia time to escape with the survivors. Her death was avenged by Malia after she and Tristan killed Sandrino. She reprised her role from
Imortal. •
Jethro Kabigting, portrayed by
Dino Imperial, a seer from
Imortal series,
Enrico "Tikboy" Kabigting's son and
Trixie's nephew. His family are
psychics who long serve the Waya Inc., an organization that governs all werewolves, coordinates with the mortals’ government, and protects mortals from vampires. He sees visions through
psychometry and can communicate with other seers using
telepathy. He is captured and imprisoned by Sandrino for fourteen years, and as a result, the LLU does not have crucial psychic guidance to battle Supremo. He escapes and reunites with Malia and the LLU. From the Ancient Book of Spells he learns that the cursed ink harnesses its power from a heart consumed with anger and hatred, rid of humanity. He reprises his role from
Imortal. •
Clarisse Zaragoza, portrayed by
Niña Dolino, a black werewolf and LLU/Waya Council member, she was the daughter of former veteran Waya member Lucille Zaragoza. She was originally an enemy to Lia though became Lia’s ally in the end. She was part of the original Waya Board. She sacrificed herself to protect Lia, Matteo, and Malia from Sandrino. Her death was avenged by Malia after she and Tristan killed Sandrino. She reprised her role from
Imortal. •
Erin, portrayed by
Polo Ravales, a high ranking Luna officer and later the de facto leader, and part of the rebuilt LLU. He was deeply traumatized by the death of his Luna comrades that it made him believe that there isn't any good in both werewolves and vampires. This led to him to defy LLU and Malia's orders and defected from the group along with the remaining Luna soldiers. He was later captured and killed by Sandrino after attempting to kill his half-brother, Tristan, who was the prophesied enemy of Malia. •
Diana, portrayed by
Sam Pinto, a human turned vampire who is Sandrino's lover and second-in command. She fought the werewolves and LLU vampires during the massacre. She took a job as a bartender in Sandrino's club called Heat Bar as a cover for her activities. She is killed in cold blood by Sandrino after he thought that she was betraying him. •
Luningning "Ningning" Ramos is portrayed by
Kristel Fulgar (adult) and
Elia Ilano (child), childhood friend of Malia in San Isidro, Nognog's best friend and girlfriend. She is a games and computer wizard. A celebrity in her own right as the
eSports champion of DATU Asian Tournament (Final Round), she is recruited to work as celebrity endorser and ambassador for Youtopia. Later in the series, she reunites with Malia and becomes a spy for Malia in Gilbert's camp. Jacintha rescues her and she becomes part of Malia's staff in Waya Farms. •
Apple Torralba, portrayed by
Maymay Entrata, the only natural child of Tonio and Rica Toralba. She is Tristan's half-sister, born after Rica joins the Toralbas as Tonio's wife. After Tristan's “death”, she inherits her brother's Trust Fund left by their mother, Rica, bringing the surviving Toralbas out of poverty with substantial funds to live on. •
Gabriel Torralba, portrayed by Noel Trinidad, is Tristan and Apple's grandfather. He knows that Tristan is not Tonio's child when the infant suffers a health crisis, but keeps the information secret out of respect for Tonio and Rica's wishes. He loves Tristan as his grandson. He is killed by Sandrino after being taken hostage by him. But in the finale, Sandrino is killed by Tristan and Malia, avenging his death. •
Pina Torralba, portrayed by Debraliz Valasote, is Tristan and Apple's grandmother. She is killed by Sandrino after being taken hostage by him. But in the finale, Sandrino is killed in the final battle by Tristan and Malia, avenging her death. •
Noel "Doc" Domingo, portrayed by
Randy Santiago, is Tristan's surrogate father while growing up, and Betty's fiancé. They get married on the same day vampires kill her. He looks after the surviving Toralbas after the war and moves in with the Toralbas in their mansion. He is Collin's biological father. •
Summer Sison, portrayed by
Desiree del Valle, Tristan and Apple's aunt, Rica's eldest sister, who Tristan grows up with after his father died. Tristan works as a driver and mechanic for her operations. She is assigned as trustee for Tristan's Trust Fund which he inherits from his mother Rica when he turns 21. The Trust is her sole agenda for keeping Tristan. She tries to deplete the trust fund by deducting made up debts. •
Miguel, portrayed by Michael Agassi, a vampire, one of LLU's right hand members under Frederick's leadership, and trainer for the young werewolves and vampires. He met his end during the massacre by Sandrino's lover and one of his vampires, Diana. His death was avenged by Malia after she and Tristan killed Sandrino. •
Nora, portrayed by Mikylla Ramirez, a white wolf, Malia’s friend, and LLU member. She turned into a werewolf on her birthday. She was killed by vampires during the massacre and was avenged by Malia after she and Tristan killed Sandrino. •
Bogart , portrayed by Hyubs Azarcon, is Tristan's friend and co-mechanic, also living with the Toralbas in their mansion. •
Collin Domingo, portrayed by
Edward Barber, is Apple's bodyguard and one of the housekeepers of the Torralbas in their new home. He is Doc's long lost son. •
Dolores "Dory" Lumakad, portrayed by
Sylvia Sanchez, the mother of Miyo and the wife of Gilbert. ==Extended cast==