Loke's business gradually grew and he left his staff and nephew, Cheong Yoke Choy, in charge of the store while he travelled to northern Malaya, particularly
Perak to explore the tin mining business. Loke's initial mines at
Kamunting did fairly well but tin prices fell during the
Larut Wars which affected his business. After the Larut Wars and the
Perak War, the
Kinta District of Perak was opened up and Loke managed to re-established himself back in Perak.Loke would then went on to acquire and own many more
tin mines, and rubber and
coconut plantations in Perak. He also ventured into the pawnbroking business, and even obtained monopoly for liquor sales, gambling licences and other privileges from the colonial government. Loke's other assets included several hundred hectares of land, real estate and properties in both Singapore,
Malaya, Hong Kong and China. Loke Yew was the largest shareholder in Pahang Motor Car Service, owned shares in the
Raub Straits Trading Company,
Straits Steamship and Federal Engineers, partly owned Burmah Rice Mill, made investments in properties all over Singapore and Malaya. He played a leading role along with his nephews (sons of one of his sisters) named Cheong Yoke Choy and Cheong Yoke Choong in establishing
Kwong Yik Bank, which opened in July 1915. Loke also went into partnership with
Thamboosamy Pillai in managing the New Tin Mining Company in
Rawang. They were the first to use electric pumps for mining in Malaya. In 1936, his son,
Loke Wan Tho, along with his fourth wife,
Lim Cheng Kim established Associated Theatres Ltd—later renamed
Cathay Organisation. In 1939, the Loke conglomerate built Singapore's first skyscraper, the
Cathay Building. ==Personal life==