Lokesh made his directorial debut with the short film,
Acham Thavir (2012), which won awards for Best Director, Best Film and Best Actor at the Clubace short film festival. He directed his first feature film,
Maanagaram, in 2017, followed by the 2019 action thriller
Kaithi produced by
Dream Warrior Pictures, with
Karthi in the lead role. Lokesh's next film,
Master, released in January 2021 and starring
Vijay and
Vijay Sethupathi, received positive reviews and became the highest-grossing Indian film of that year. In 2022, Lokesh directed
Vikram, starring
Kamal Haasan, Vijay Sethupathi and
Fahadh Faasil. The film’s success, along with the establishment of the
Lokesh Cinematic Universe (LCU), elevated his reputation in the industry, leading to another collaboration with Vijay on
Leo (2023). It
became one of the highest grossing Indian films by earning over worldwide and served as the third installment in the LCU franchise. In June 2023, Lokesh announced to conclude his directing career after completing 10 films. Later that year, in December, Lokesh announced a short film within the LCU, titled
Chapter Zero, as a prequel to
Kaithi 2. Lokesh Kanagaraj and
Shruti Haasan come together for a musical project titled
Inimel (2024). Following the release of
Leo, Lokesh announced he would be directing the 171st film of
Rajinikanth,
Coolie (2025), produced by
Sun Pictures and with music composed by
Anirudh Ravichander. It marked Lokesh’s first collaboration with
Rajinikanth and was conceived as a standalone film separate from the
Lokesh Cinematic Universe (LCU). It released worldwide on 14 August 2025 to mixed reviews from both critics and audience alike, with significant box-office collections reported across India and overseas markets. On 14 January 2026, coinciding with
Sankranthi and
Pongal, Lokesh announced he would be directing the 23rd film of
Allu Arjun, produced by
Mythri Movie Makers and with music composed by Anirudh Ravichander.
G Squad In November 2023, Lokesh launched his production company, G Squad, and unveiled his first production,
Fight Club, directed by
Vijay Kumar. On 14 April 2024 coinciding with
Puthandu, Lokesh announced his production venture,
Benz, directed by
Bakkiyaraj Kannan and starring
Raghava Lawrence in the lead. He has also written the story for the film. On 30 October 2024,
Benz was confirmed to be a part of the LCU. A few weeks later, Lokesh announced
Mr Bhaarath, an upcoming Tamil-language romantic comedy, on 18 December 2024, to be produced under his G Squad banner. On 12 December 2025,
Rathna Kumar’s fourth directorial venture,
29, was announced as a co-production by Lokesh and
Karthik Subbaraj under the banners G Squad and
Stone Bench. == Filmmaking style ==