Early career Lookboonmee began training Muay Thai at seven years old at her father Boonmee Suphisara's gym. She began competing against girls, but soon was facing boys due to the lack of competition. She eventually gained several titles and competed for the Thai national team. Lookboonmee transitioned to mixed martial arts in 2017, training under coach George Hickman at Tiger Muay Thai. She won the bout, submitting
Filipina fighter Krisna Limbaga by
rear naked choke in the second round, She made her professional debut in January 2018 at Invicta FC 27. She amassed a record of three wins against one loss before going to the UFC.
Ultimate Fighting Championship In September 2019, it was announced that Lookboonmee had signed with the UFC. She made her debut against
Aleksandra Albu at
UFC on ESPN+ 20. She won the fight via split decision. Lookboonmee was scheduled to face
Hannah Goldy on February 23, 2020 at
UFC Fight Night 168. However, Goldy pulled out due to a shoulder injury and was replaced by
Angela Hill. She lost the fight via unanimous decision. Lookboonmee faced
Jinh Yu Frey on October 4, 2020 at
UFC on ESPN: Holm vs. Aldana. She won the fight via unanimous decision. As the first bout of her new multi-fight contract, Lookboonmee faced
Sam Hughes on May 1, 2021 at
UFC on ESPN: Reyes vs. Procházka. She won the bout via unanimous decision. Lookboonmee was scheduled to face
Cheyanne Buys on November 20, 2021 at
UFC Fight Night 198. However, Buys withdrew from the bout for undisclosed reasons and she was replaced by
Lupita Godinez. She lost the bout via unanimous decision. Lookboonmee was scheduled to face
Diana Belbiţă on September 17, 2022 at
UFC Fight Night 210. However, Belbiţă withdraw due to undisclosed reason and was replaced by
Denise Gomes. Lookboonmee won the fight via unanimous decision. As the first bout of her new multi-fight contract, Lookboonmee was scheduled to face
Elise Reed on February 4, 2023, at
UFC Fight Night 218. However, the pair was moved to
UFC 284 for undisclosed reasons. She won the fight via a rear-naked choke submission in the second round. Lookboonmee faced Bruna Brasil on February 10, 2024, at
UFC Fight Night 236, winning the fight via unanimous decision. Lookboonmee was scheduled to face
Ariane Carnelossi on April 5, 2025 at
UFC on ESPN 65. However, Carnelossi withdrew from the fight due to an ankle injury and was replaced by Istela Nunes. She won the fight via unanimous decision. She lost the fight by unanimous decision. Lookboonmee is scheduled to face Jacqueline Amorim on May 30, 2026, at
UFC Fight Night 277. ==Championships and achievements==