The route of LA 73 was originally called "Clay Cut Road," as it roughly followed the Claycut Bayou through the southern part of East Baton Rouge Parish. Other names for the road were Hope Villa Road, as it traversed through the community of Hope Villa in Ascension Parish. When the
Jefferson Highway auto trail was designated in 1916, Clay Cut and Hope Villa Roads became part of the new road (there is now another Claycut Road in Baton Rouge, located south of the present-day LA-73). When Louisiana numbered their highways in 1921 plan, Jefferson Highway was designated Louisiana Highway 1. US 61 followed the section between Prairieville and the Mississippi River from 1926 until 1933 when the Airline Highway was opened between Prairieville and the
Bonnet Carré Spillway. US 61 remained on the section between Prairieville and Baton Rouge until 1941, when Airline Highway was extended into Baton Rouge. As of 2018, the portion west of
LA 948 is under agreement to be removed from the state highway system and transferred to local control. ==Major junctions==