Pre-1955 route numbering In the
original Louisiana Highway system in use between 1921 and 1955, the modern LA 99 was part of three separate routes.
Southern section The section from the southern terminus west of Lake Arthur to the present intersection with LA 102 southeast of Fenton made up the majority of
State Route 105. It was designated in 1926 by an act of the state legislature. North of Welsh, Route 105 turned west to follow the modern route of LA 102 to Fenton, located along US 165. The route description identifies the northern terminus as
State Route 24, which was co-signed with US 165 throughout the pre-1955 era. The portion of Route 105 that is now followed by LA 99 has remained virtually the same apart from the route through Welsh. Just before crossing into the south end of town, the pre-1955 route made a brief jog eastward onto a parallel road. After about , it made a second jog back onto the current alignment at Frey Road. The route then continued into Welsh, where it turned west onto Derouen Street then north onto Adams Street, continuing straight across US 90 onto the current alignment.
Northern section From the point where former State Route 105 turned west toward Fenton, a section of
State Route 735 continued the modern route of LA 99 north then east for to Pine Island.
State Route 714 then covered the remainder of the present LA 99 north to Lauderdale. The route description reflects the fact that prior to 1935, when US 190 was extended west of the
Mississippi River over former
State Route 7, its route was generally called the
Evangeline Highway. Route 714 remained virtually the same up to the 1955 renumbering. The route through Welsh was changed less than a year following the 1955 renumbering. The route of LA 99 has otherwise remained the same to the present day. ==Major intersections==