I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.
Human proteins containing this domain
•
ADAMTSL1,
ADAMTSL3,
ALPK3,
AXL, •
BOC, •
C9orf94,
CADM2,
CADM4,
CCDC141,
CDON,
CEACAM7,
CHL1,
CILP2,
CNTN1,
CNTN2,
CNTN3,
CNTN4,
CNTN5,
CNTN6,
CXADR, •
DCC,
DSCAM,
DSCAML1, •
ESAM, •
FGFR1,
FGFR3,
FGFR4,
FGFRL1,
FLT1,
FLT4,
FSTL4,
FSTL5, •
HMCN1,
HNT,
HSPG2, •
ICAM5,
IGFBP7,
IGFBPL1,
IGSF10,
IGSF22,
IGSF9,
ISLR, •
KALRN,
KAZALD1,
KDR,
KIAA0626,
KIRREL,
KIRREL2,
KIRREL3, •
L1CAM,
LINGO1,
LINGO2,
LRFN2,
LRFN3,
LRFN4,
LRFN5,
LRIG1,
LRIG2,
LRIG3,
LRIT2,
LRIT3,
LRRC24,
LRRC4B,
LRRC4C,
LRRN1,
LRRN3,
LRRN5,
LSAMP, •
MAG,
MDGA2,
MFAP3L,
MUSK,
MXRA5,
MYBPC1,
MYBPC2,
MYBPC3,
MYBPH,
MYBPHL,
MYLK,
MYOM1,
MYOM2,
MYOM3,
MYOT,
MYPN, •
NCAM1,
NCAM2,
NEGR1,
NEO1,
NEXN,
NFASC,
NGL1,
NOPE,
NPHS1,
NPTN,
NRCAM,
NRG2,
NT,
NTRK2,
NTRK3, •
OBSCN,
OBSL1,
OPCML, •
PALLD,
PAPLN,
PDGFRA,
PRODH2,
PTK7,
PTPRD,
PTPRF,
PTPRS,
PTPsigma,
PUNC, •
ROBO1,
ROBO2,
ROBO3,
ROBO4,
ROR1,
ROR2, •
SDK1,
SDK2,
SIGLEC1,
SIGLEC6,
SPEG, •
TRIO,
TTN, •
UNC5A,
UNC5B,
UNC5C, •
VCAM1,
WFIKKN1,
WFIKKN2, ==References==