Feyenoord On 8 July 2018, Sinisterra signed a three-year contract with an option for two more years with
Feyenoord for a reported fee of €2 million. He scored his first goal for the club on 8 August 2019, scoring the opening goal in
third qualifying round of the 2019–20 UEFA Europa League against
FC Dinamo Tbilisi. On 7 February 2020, Sinisterra won the prize for Eredivisie Player of the Month under-21 for the month of January 2020 after scoring in three consecutive matches. On 12 November 2020, Feyenoord announced that the club had used the option in Sinisterra's contract to extend his contract with another two years. On 19 August 2021, Sinisterra scored a hat-trick in the
first leg of their
UEFA Europa Conference League play-off round tie against
Swedish club
IF Elfsborg.
Leeds United On 7 July 2022, Sinisterra joined
Leeds United on a five-year contract for a transfer fee of £21 million. Following his transfer to Leeds he became the most expensive outgoing transfer in Feyenoord's history. Sinisterra scored his first goal for the club in a 3–1 win against
Barnsley in the
EFL Cup second round at Elland Road, he then scored his first Premier League goal days later, the equaliser in a 1–1 home draw against
Everton. Despite suffering injury spells out of the team in November 2022 through mid-January 2023, and for the final, crucial five games of the season in April/May, he finished the season as the club's
second-highest scorer in all competitions after
Rodrigo.
Bournemouth On 2 September 2023, it was announced that
Bournemouth had signed Sinisterra from Leeds United on a season-long loan swap deal with
Jaidon Anthony on the last day of the summer transfer window after pledging to stay with Leeds to young fans hours before. On 9 February 2024, after having scored three goals and provided three assists in 17 appearances in all competitions, Sinisterra joined Bournemouth on a permanent deal, for a reported transfer fee of £20 million with the transfer formally to be completed in the summer 2024 transfer window. On 31 August, he scored the winning goal in stoppage time of a 3–2 victory over Everton.
Cruzeiro On 22 August 2025, Sinisterra joined Brazilian side
Cruzeiro on a loan. The deal included a £2 million up front fee along with an obligation to make the deal permanent at the end of the loan worth £10 million. ==International career==