Early career Born in
Vitória, Espírito Santo, Lyanco started his youth career at
Botafogo. He started and played the 90 minutes in his third professional match, a 0–0 draw against
Joinville.
Torino On 29 March 2017, it was announced that Lyanco had signed a five-year contract with
Serie A club
Torino, for a reported fee of €6 million plus bonuses. He immediately moved to Turin to begin training with the team, and facilitate his acclimatisation to the club, at the orders of
Siniša Mihajlović.
Bologna (loan) On 31 January 2019, Lyanco joined
Bologna on loan until 30 June 2019.
Southampton On 25 August 2021, Lyanco joined
Southampton on a four-year deal for an undisclosed fee. On 21 September 2021, he made his first appearance for Southampton in the
EFL Cup against
Sheffield United which ended 2–2, with Southampton advancing 4–2 on penalties. On 30 October 2021, Lyanco made his first
Premier League appearance, replacing
Oriol Romeu in Southampton's 1–0 win against
Watford at
Vicarage Road. He was forced off with a hamstring injury in the first half of Southampton's
FA Cup match against
Coventry City on 5 February 2022, and was expected to be sidelined for up to 12 weeks. On 16 April 2022, Lyanco returned from injury and appeared in a 1–0 victory against
Arsenal. On 8 May 2023, Lyanco scored his first
Premier League goal in a 4–3 defeat to
Nottingham Forest. He went to
Istanbul for transfer negotiations with
Beşiktaş on 19 July 2023, but the transfer collapsed due to a change in the terms of the agreement proposed to Southampton.
Al-Gharafa (loan) On 29 August 2023, Lyanco joined
Al-Gharafa on a season-long loan. Three days later, he made his debut for the club in a 1–4 victory against
Al Ahli. On 28 September 2023, Lyanco was given a
red card for violent conduct during a 4–0 defeat to
Al Sadd. He scored his first goal for the club on 11 March 2024 in a 0–2 victory against
Muaither.
Atlético Mineiro On 5 July 2024, Lyanco joined
Atlético Mineiro for an undisclosed fee. In October 2025, he suffered a rupture of his left Achilles tendon and had to undergo surgery. On 8 March 2026, Lyanco was punched in a mass brawl during the
Campeonato Mineiro final against
Cruzeiro which led to 23 red cards being handed out, a record for a single fixture in Brazilian football. ==International career==