Macrotritopus is a poorly known genus of octopuses in the family Octopodidae. As it stands, Macrotritopus contains two valid described species, Macrotritopus defilippi from the NE Atlantic and Mediterranean, and Macrotritopus beatrixi from the Caribbean and SW Atlantic. Two poorly described, unresolved taxa are known only from planktonic hatchlings, and a further three undescribed Indo-Pacific species may be attributable to this genus.